Buckling-Based Method for Evaluating Young's Modulus of Microfiber and Predicting Cell Growth

Kaihao Wen, Xie Chen, Qing Shi, Huaping Wang, Qiang Huang, Toshio Fukuda, Tao Sun

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Variety of microfibers have been widely utilized as a promising bioink for 3D bioprinting. However, the mechanical properties of the cell-laden microfiber are difficult to be characterized precisely due to the lack of low-damage loading methods for encapsulated cells that require a relatively short loading time. In this paper, we propose a bulking-based method for rapidly evaluating the Young's modulus, Ec of the microfibers within several seconds. A two-probe based micromanipulation system is utilized to compress the microfiber. Based on the computer vision, the compression force is measured and used for calculating the Ec according to the Euler column formula, and it is found that the evaluation results of Ec can be improved in a high compression speed. Moreover, the precision of measure Ec is guaranteed and the value is close to the other loading methods. The results show the proposed method can realize a high precise measurement in about 2s which is faster than other methods. Additionally, the measured Ec is used to predict the cell growth of cell-laden microfibers in the next few days, demonstrating its potential for speeding up the screening of biocompatible materials.

Original languageEnglish
Title of host publication2023 42nd Chinese Control Conference, CCC 2023
PublisherIEEE Computer Society
Pages6812-6817
Number of pages6
ISBN (Electronic)9789887581543
DOIs
Publication statusPublished - 2023
Event42nd Chinese Control Conference, CCC 2023 - Tianjin, China
Duration: 24 Jul 202326 Jul 2023

Publication series

NameChinese Control Conference, CCC
Volume2023-July
ISSN (Print)1934-1768
ISSN (Electronic)2161-2927

Conference

Conference42nd Chinese Control Conference, CCC 2023
Country/TerritoryChina
CityTianjin
Period24/07/2326/07/23

Keywords

  • ARMA
  • Buckling
  • EEMD
  • Microfiber
  • Modeling and prediction
  • Young's modulus

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