Bioinspired interface design modulates pathogen and immunocyte responses in biomaterial-centered infection combination therapy

Jinhua Li; Wei Liu; David Kilian; Xianlong Zhang; Michael Gelinsky; Paul K. Chu

doi:10.1039/c8mh01606b

Bioinspired interface design modulates pathogen and immunocyte responses in biomaterial-centered infection combination therapy

Jinhua Li, Wei Liu, David Kilian, Xianlong Zhang^*, Michael Gelinsky, Paul K. Chu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The rise of multidrug-resistant pathogens and the dearth of novel antibiotic development means that breakthrough strategies that go beyond the classical antibiotic mechanism are urgently required to fight this approaching human health cataclysm. Herein, inspired by the metabolism cascade of pathogens and the clearance of infection by the host immune system, a new three-step strategy is reported to achieve combination therapy of biomaterial-centered infections. Band-structure-tunable cobalt doped TiO₂ semiconductor can effectively restrain bacterial biofilm formation and enhance phagocytosing and killing of bacteria by immune cells. Released Co²⁺ ions can produce a proinflammatory microenvironment and potentiate the antibacterial capability of immune cells. This design concept can be applied to develop other antibacterial biomaterials, and holds great promise for advanced biomaterial-centered infection therapy.

Original language	English
Pages (from-to)	1271-1282
Number of pages	12
Journal	Materials Horizons
Volume	6
Issue number	6
DOIs	https://doi.org/10.1039/c8mh01606b
Publication status	Published - Jul 2019
Externally published	Yes

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title = "Bioinspired interface design modulates pathogen and immunocyte responses in biomaterial-centered infection combination therapy",

abstract = "The rise of multidrug-resistant pathogens and the dearth of novel antibiotic development means that breakthrough strategies that go beyond the classical antibiotic mechanism are urgently required to fight this approaching human health cataclysm. Herein, inspired by the metabolism cascade of pathogens and the clearance of infection by the host immune system, a new three-step strategy is reported to achieve combination therapy of biomaterial-centered infections. Band-structure-tunable cobalt doped TiO2 semiconductor can effectively restrain bacterial biofilm formation and enhance phagocytosing and killing of bacteria by immune cells. Released Co2+ ions can produce a proinflammatory microenvironment and potentiate the antibacterial capability of immune cells. This design concept can be applied to develop other antibacterial biomaterials, and holds great promise for advanced biomaterial-centered infection therapy.",

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AU - Liu, Wei

AU - Kilian, David

AU - Zhang, Xianlong

AU - Gelinsky, Michael

AU - Chu, Paul K.

PY - 2019/7

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AB - The rise of multidrug-resistant pathogens and the dearth of novel antibiotic development means that breakthrough strategies that go beyond the classical antibiotic mechanism are urgently required to fight this approaching human health cataclysm. Herein, inspired by the metabolism cascade of pathogens and the clearance of infection by the host immune system, a new three-step strategy is reported to achieve combination therapy of biomaterial-centered infections. Band-structure-tunable cobalt doped TiO2 semiconductor can effectively restrain bacterial biofilm formation and enhance phagocytosing and killing of bacteria by immune cells. Released Co2+ ions can produce a proinflammatory microenvironment and potentiate the antibacterial capability of immune cells. This design concept can be applied to develop other antibacterial biomaterials, and holds great promise for advanced biomaterial-centered infection therapy.

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Bioinspired interface design modulates pathogen and immunocyte responses in biomaterial-centered infection combination therapy

Abstract

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