TY - JOUR
T1 - Biohybrid Magnetic Microrobots for Tumor Assassination and Active Tissue Regeneration
AU - Liu, Dong
AU - Zhang, Ting
AU - Guo, Yijia
AU - Liao, Yuting
AU - Wu, Zijian
AU - Jiang, Hao
AU - Lu, Yuan
N1 - Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/12/19
Y1 - 2022/12/19
N2 - Magnetic microrobots have attracted increasing research interest for diverse biomedical applications, such as targeted therapy and tissue regeneration. However, multifunctional microrobots with complex morphology at the microscale are urgently needed to be fabricated, actively controlled, and functionalized. In this study, the chrysanthemum pollen-derived biohybrid magnetic microrobots (CDBMRs) with spiny protrusion, hollow cavity, and porous surface structure were proposed for tumor assassination and active tissue regeneration. By exquisitely designing the sequential treatment process, CDBMRs were fabricated and the innate morphology of pollen templates was well preserved. Under magnetic field, CDBMR exhibited various individual and collective behaviors. CDBMRs were utilized for synergetic tumor treatment by the combination of magnetically controlled physical assassination and active drug delivery. Meanwhile, CDBMRs showed excellent ability for active cell delivery and tissue regeneration, which was further proved by enhanced osteogenesis ability. By making full use of the natural morphology of pollen grains, the biohybrid microrobots presented a promising strategy for effective tumor therapeutics and tissue regeneration. copy; 2022 American Chemical Society.
AB - Magnetic microrobots have attracted increasing research interest for diverse biomedical applications, such as targeted therapy and tissue regeneration. However, multifunctional microrobots with complex morphology at the microscale are urgently needed to be fabricated, actively controlled, and functionalized. In this study, the chrysanthemum pollen-derived biohybrid magnetic microrobots (CDBMRs) with spiny protrusion, hollow cavity, and porous surface structure were proposed for tumor assassination and active tissue regeneration. By exquisitely designing the sequential treatment process, CDBMRs were fabricated and the innate morphology of pollen templates was well preserved. Under magnetic field, CDBMR exhibited various individual and collective behaviors. CDBMRs were utilized for synergetic tumor treatment by the combination of magnetically controlled physical assassination and active drug delivery. Meanwhile, CDBMRs showed excellent ability for active cell delivery and tissue regeneration, which was further proved by enhanced osteogenesis ability. By making full use of the natural morphology of pollen grains, the biohybrid microrobots presented a promising strategy for effective tumor therapeutics and tissue regeneration. copy; 2022 American Chemical Society.
KW - biohybrid microrobots
KW - cell delivery
KW - magnetic control
KW - pollen
KW - tissue regeneration
KW - tumor assassination
UR - http://www.scopus.com/inward/record.url?scp=85142613694&partnerID=8YFLogxK
U2 - 10.1021/acsabm.2c00880
DO - 10.1021/acsabm.2c00880
M3 - Article
C2 - 36384280
AN - SCOPUS:85142613694
SN - 2576-6422
VL - 5
SP - 5933
EP - 5942
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 12
ER -