Biohybrid Magnetic Microrobots for Tumor Assassination and Active Tissue Regeneration

Dong Liu, Ting Zhang, Yijia Guo, Yuting Liao, Zijian Wu, Hao Jiang, Yuan Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Magnetic microrobots have attracted increasing research interest for diverse biomedical applications, such as targeted therapy and tissue regeneration. However, multifunctional microrobots with complex morphology at the microscale are urgently needed to be fabricated, actively controlled, and functionalized. In this study, the chrysanthemum pollen-derived biohybrid magnetic microrobots (CDBMRs) with spiny protrusion, hollow cavity, and porous surface structure were proposed for tumor assassination and active tissue regeneration. By exquisitely designing the sequential treatment process, CDBMRs were fabricated and the innate morphology of pollen templates was well preserved. Under magnetic field, CDBMR exhibited various individual and collective behaviors. CDBMRs were utilized for synergetic tumor treatment by the combination of magnetically controlled physical assassination and active drug delivery. Meanwhile, CDBMRs showed excellent ability for active cell delivery and tissue regeneration, which was further proved by enhanced osteogenesis ability. By making full use of the natural morphology of pollen grains, the biohybrid microrobots presented a promising strategy for effective tumor therapeutics and tissue regeneration. copy; 2022 American Chemical Society.

Original languageEnglish
Pages (from-to)5933-5942
Number of pages10
JournalACS Applied Bio Materials
Volume5
Issue number12
DOIs
Publication statusPublished - 19 Dec 2022

Keywords

  • biohybrid microrobots
  • cell delivery
  • magnetic control
  • pollen
  • tissue regeneration
  • tumor assassination

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Liu, D., Zhang, T., Guo, Y., Liao, Y., Wu, Z., Jiang, H., & Lu, Y. (2022). Biohybrid Magnetic Microrobots for Tumor Assassination and Active Tissue Regeneration. ACS Applied Bio Materials, 5(12), 5933-5942. https://doi.org/10.1021/acsabm.2c00880