Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

Duo Wang; Chengkai Zhang; Li Ren; Dongdong Li; Jihong Yu

doi:10.1039/c7qi00575j

Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

Duo Wang, Chengkai Zhang, Li Ren, Dongdong Li, Jihong Yu^*

^*Corresponding author for this work

Jilin University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60-100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg^-1 and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.

Original language	English
Pages (from-to)	474-480
Number of pages	7
Journal	Inorganic Chemistry Frontiers
Volume	5
Issue number	2
DOIs	https://doi.org/10.1039/c7qi00575j
Publication status	Published - Feb 2018
Externally published	Yes

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title = "Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging",

abstract = "Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60-100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg-1 and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.",

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T1 - Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

AU - Wang, Duo

AU - Zhang, Chengkai

AU - Ren, Li

AU - Li, Dongdong

AU - Yu, Jihong

PY - 2018/2

Y1 - 2018/2

N2 - Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60-100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg-1 and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.

AB - Inorganic bioactive nanomaterials play a significant role in biomedical fields due to their excellent biocompatibility. AIEgen-functionalised mesoporous bioactive glass (FMBG) nanoparticles with sizes of 60-100 nm are prepared by post-grafting tetraphenylethene onto bioactive glass. The obtained nanoparticles emit strong blue light at 482 nm upon UV irradiation, showing potential application in cell imaging. Furthermore, the FMBG, with a high DOX loading capacity of 250.74 μg mg-1 and good degradability in an acid environment, can be used for cancer treatment. The degradability of FMBG increases the release efficiency of DOX in the acid environment. The as-prepared hybrid nanoparticles may act as a promising drug delivery system due to their high drug loading capacity, pH sensitivity, good biodegradability, and biocompatibility.

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Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging

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