Assembled Fe3O4 nanoparticles on Zn–Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity

Juanhua Chai; Yingying Ma; Tonglai Guo; Ying He; Guangshuo Wang; Fangfang Si; Jiahong Geng; Xiongwei Qi; Guoqing Chang; Zhigang Ren; Ruitao Yu; Liye Song; Dong Li

doi:10.1016/j.clay.2022.106630

Assembled Fe₃O₄ nanoparticles on Zn–Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity

Juanhua Chai, Yingying Ma, Tonglai Guo, Ying He, Guangshuo Wang^*, Fangfang Si, Jiahong Geng, Xiongwei Qi, Guoqing Chang, Zhigang Ren, Ruitao Yu, Liye Song, Dong Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

This article presented a facile two-step hydrothermal strategy to anchor the Fe₃O₄ nanoparticles on the surface of Zn–Al LDH nanosheets, and investigated systematically the potential application of the constructed Fe₃O₄/Zn-Al LDH nanocomposites in the biomedical field of controlled drug delivery. It was revealed that the formed Fe₃O₄/Zn-Al LDH nanocomposites exhibited uniform mesopores, high surface area of 121.7 m²/g, good superparamagnetism and appropriate saturation magnetization of 40.7 emu/g. Due to these fascinating properties, this work explored the application of Fe₃O₄/Zn-Al LDH in the field of nanocarrier using the doxorubicin hydrochloride (DOX) as a model anticancer drug for the detailed investigations of drug loading capacity, controlled release behavior and cytotoxic effects under in vitro conditions. The Fe₃O₄/Zn-Al LDH showed a good drug storage capacity and a pH-responsive drug release profile. After loading the anti-cancer drugs, the DOX-loaded Fe₃O₄/Zn-Al LDH exhibited enhanced therapeutic effect on human hepatocellular carcinoma cells (HepG2), demonstrating that the fabricated Fe₃O₄/Zn-Al LDH nanocomposites have a great potential in cancer therapy.

Original language	English
Article number	106630
Journal	Applied Clay Science
Volume	228
DOIs	https://doi.org/10.1016/j.clay.2022.106630
Publication status	Published - Oct 2022
Externally published	Yes

Keywords

Controlled drug release
Cytotoxicity
FeO
Nanocomposites
Zn-Al-LDH

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.clay.2022.106630

Cite this

Chai, J., Ma, Y., Guo, T., He, Y., Wang, G., Si, F., Geng, J., Qi, X., Chang, G., Ren, Z., Yu, R., Song, L., & Li, D. (2022). Assembled Fe₃O₄ nanoparticles on Zn–Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity. Applied Clay Science, 228, Article 106630. https://doi.org/10.1016/j.clay.2022.106630

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abstract = "This article presented a facile two-step hydrothermal strategy to anchor the Fe3O4 nanoparticles on the surface of Zn–Al LDH nanosheets, and investigated systematically the potential application of the constructed Fe3O4/Zn-Al LDH nanocomposites in the biomedical field of controlled drug delivery. It was revealed that the formed Fe3O4/Zn-Al LDH nanocomposites exhibited uniform mesopores, high surface area of 121.7 m2/g, good superparamagnetism and appropriate saturation magnetization of 40.7 emu/g. Due to these fascinating properties, this work explored the application of Fe3O4/Zn-Al LDH in the field of nanocarrier using the doxorubicin hydrochloride (DOX) as a model anticancer drug for the detailed investigations of drug loading capacity, controlled release behavior and cytotoxic effects under in vitro conditions. The Fe3O4/Zn-Al LDH showed a good drug storage capacity and a pH-responsive drug release profile. After loading the anti-cancer drugs, the DOX-loaded Fe3O4/Zn-Al LDH exhibited enhanced therapeutic effect on human hepatocellular carcinoma cells (HepG2), demonstrating that the fabricated Fe3O4/Zn-Al LDH nanocomposites have a great potential in cancer therapy.",

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author = "Juanhua Chai and Yingying Ma and Tonglai Guo and Ying He and Guangshuo Wang and Fangfang Si and Jiahong Geng and Xiongwei Qi and Guoqing Chang and Zhigang Ren and Ruitao Yu and Liye Song and Dong Li",

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doi = "10.1016/j.clay.2022.106630",

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AU - Chai, Juanhua

AU - Ma, Yingying

AU - Guo, Tonglai

AU - He, Ying

AU - Wang, Guangshuo

AU - Si, Fangfang

AU - Geng, Jiahong

AU - Qi, Xiongwei

AU - Chang, Guoqing

AU - Ren, Zhigang

AU - Yu, Ruitao

AU - Song, Liye

AU - Li, Dong

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AB - This article presented a facile two-step hydrothermal strategy to anchor the Fe3O4 nanoparticles on the surface of Zn–Al LDH nanosheets, and investigated systematically the potential application of the constructed Fe3O4/Zn-Al LDH nanocomposites in the biomedical field of controlled drug delivery. It was revealed that the formed Fe3O4/Zn-Al LDH nanocomposites exhibited uniform mesopores, high surface area of 121.7 m2/g, good superparamagnetism and appropriate saturation magnetization of 40.7 emu/g. Due to these fascinating properties, this work explored the application of Fe3O4/Zn-Al LDH in the field of nanocarrier using the doxorubicin hydrochloride (DOX) as a model anticancer drug for the detailed investigations of drug loading capacity, controlled release behavior and cytotoxic effects under in vitro conditions. The Fe3O4/Zn-Al LDH showed a good drug storage capacity and a pH-responsive drug release profile. After loading the anti-cancer drugs, the DOX-loaded Fe3O4/Zn-Al LDH exhibited enhanced therapeutic effect on human hepatocellular carcinoma cells (HepG2), demonstrating that the fabricated Fe3O4/Zn-Al LDH nanocomposites have a great potential in cancer therapy.

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