@inproceedings{135707ed97a8465aae6d667077b24e6c,
title = "Are there folding pathways in the functional stages of intrinsically disordered proteins?",
abstract = "We proceed from the description of protein folding by means of molecular dynamics (MD) simulations with all-atom force fields, with folding pathways interpreted in terms of soliton structures, to identify possible systematic dynamical patterns of self-organisation that govern protein folding process. We perform in silico investigations of the conformational transformations of three different proteins - MYC protein (an α-helical protein), amylin and indolicidin (IDPs with different length and binding dynamics). We discuss the emergence of soliton-mediated secondary motifs, in the case of IDPs - in the context of their functional activity. We hypothesize that soliton-like quasi-ordered conformations appear as an important intermediate stage in this process.",
author = "N. Ilieva and J. Liu and R. Marinova and P. Petkov and L. Litov and J. He and Niemi, {A. J.}",
note = "Publisher Copyright: {\textcopyright} 2016 Author(s).; 8th International Conference for Promoting the Application of Mathematics in Technical and Natural Sciences, AMiTaNS 2016 ; Conference date: 22-06-2016 Through 27-06-2016",
year = "2016",
month = oct,
day = "13",
doi = "10.1063/1.4965012",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Todorov, {Michail D.}",
booktitle = "Application of Mathematics in Technical and Natural Sciences",
address = "United States",
}