Approaches to regenerate hair cell and spiral ganglion neuron in the inner ear

Muhammad Waqas, Renjie Chai*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The cochlear hair cells are the primary sensory structures accountable for interpreting the mechanical sound waves by converting into neural impulses. The degeneration of these sensory hair cells is irreversible in mammals and if severe damage occurs to the HCs, the deficit may result in permanent hearing loss. The present hearing rehabilitation approaches, including hearing aids and cochlear implants, partially restore hearing mechanism; however, the quality of perceived sound does not really match with the normal hearing ear. Therefore, much attention has been paid on developing regenerative therapies such as gene therapy and stem cells therapy to treat the damaged organ of Corti. These therapies are promising to stimulate the mechanism of regeneration/development in hair cells and spiral ganglion neuron, thus to recover deafness. This chapter specifically presents these two strategies and comprehensively explain their current applications to regenerate hair cells and spiral ganglion neurons in the mammalian inner ear.

Original languageEnglish
Title of host publicationNew Therapies to Prevent or Cure Auditory Disorders
PublisherSpringer International Publishing
Pages89-111
Number of pages23
ISBN (Electronic)9783030404130
ISBN (Print)9783030404123
DOIs
Publication statusPublished - 1 Jan 2020
Externally publishedYes

Keywords

  • Aav-based gene therapy
  • Atoh1-based gene therapy
  • Hair cell regeneration
  • Sensorineural hearing loss
  • Spiral ganglion neuron regeneration
  • Stem cell therapy

Fingerprint

Dive into the research topics of 'Approaches to regenerate hair cell and spiral ganglion neuron in the inner ear'. Together they form a unique fingerprint.

Cite this

Waqas, M., & Chai, R. (2020). Approaches to regenerate hair cell and spiral ganglion neuron in the inner ear. In New Therapies to Prevent or Cure Auditory Disorders (pp. 89-111). Springer International Publishing. https://doi.org/10.1007/978-3-030-40413-0_4