TY - JOUR
T1 - Application of psychobiotics in clinical treatment of mental disorders
T2 - Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety
AU - Cui, Jingwei
AU - Wang, Wenxin
AU - Tang, Yue
AU - Feng, Siyuan
AU - Liu, Hong
AU - Hao, Zikai
N1 - Publisher Copyright:
© 2025 The Author(s). Interdisciplinary Medicine published by Wiley-VCH GmbH on behalf of Nanfang Hospital, Southern Medical University.
PY - 2025
Y1 - 2025
N2 - Psychobiotics are a distinct category of probiotics known for their beneficial effects on human health, particularly in influencing mental well-being. Typical psychobiotics include genera such as Lactobacillus, Streptococcus, and Bifidobacterium. The gut microbiota influences bidirectional communication between the brain and the gastrointestinal (GI) system. Neurons in the enteric nervous system directly interact with neurotransmitters, short-chain fatty acids (SCFAs), gut hormones, and anti-inflammatory cytokines produced by the gut microbiota, thereby affecting signal transmission in the central nervous system. Unlike traditional probiotics, psychobiotics have the capacity to generate or stimulate the host to produce neurotransmitters, SCFAs, gut hormones, and anti-inflammatory cytokines. It is precisely this potential that has led to the widespread use of psychobiotics over the past decade to improve and treat mental disorders. This article briefly reviews the clinical applications of psychobiotics in improving and treating conditions such as neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety. It is proposed that the novel therapeutic approach of using Bacillus licheniformis as an adjuvant treatment for patients with depression shows a certain degree of feasibility. Finally, this review suggests that the current evidence regarding the improvement and treatment of mental and neurological disorders with psychobiotics is still limited. Further in-depth research is needed to clarify their effectiveness and mechanisms of action in the clinical management of various mental disorders.
AB - Psychobiotics are a distinct category of probiotics known for their beneficial effects on human health, particularly in influencing mental well-being. Typical psychobiotics include genera such as Lactobacillus, Streptococcus, and Bifidobacterium. The gut microbiota influences bidirectional communication between the brain and the gastrointestinal (GI) system. Neurons in the enteric nervous system directly interact with neurotransmitters, short-chain fatty acids (SCFAs), gut hormones, and anti-inflammatory cytokines produced by the gut microbiota, thereby affecting signal transmission in the central nervous system. Unlike traditional probiotics, psychobiotics have the capacity to generate or stimulate the host to produce neurotransmitters, SCFAs, gut hormones, and anti-inflammatory cytokines. It is precisely this potential that has led to the widespread use of psychobiotics over the past decade to improve and treat mental disorders. This article briefly reviews the clinical applications of psychobiotics in improving and treating conditions such as neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety. It is proposed that the novel therapeutic approach of using Bacillus licheniformis as an adjuvant treatment for patients with depression shows a certain degree of feasibility. Finally, this review suggests that the current evidence regarding the improvement and treatment of mental and neurological disorders with psychobiotics is still limited. Further in-depth research is needed to clarify their effectiveness and mechanisms of action in the clinical management of various mental disorders.
KW - depression
KW - gut microbiota
KW - mental disorders
KW - probiotics
KW - psychobiotics
UR - http://www.scopus.com/inward/record.url?scp=85214400743&partnerID=8YFLogxK
U2 - 10.1002/INMD.20240041
DO - 10.1002/INMD.20240041
M3 - Review article
AN - SCOPUS:85214400743
SN - 2832-6237
JO - Interdisciplinary Medicine
JF - Interdisciplinary Medicine
ER -