Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Fang Liu; Rong Ji Dai; Yu Lin Deng; Fang Lü

Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Fang Liu, Rong Ji Dai, Yu Lin Deng, Fang Lü^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC₅₀ by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

Original language	English
Pages (from-to)	1090-1093
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	34
Issue number	10
Publication status	Published - 1 Oct 2014

Keywords

Activity
Anticancer
Dragon' blood
Melanoma
Stilbenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Liu, F., Dai, R. J., Deng, Y. L., & Lü, F. (2014). Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 34(10), 1090-1093.

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title = "Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1",

abstract = "The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.",

keywords = "Activity, Anticancer, Dragon' blood, Melanoma, Stilbenes",

author = "Fang Liu and Dai, {Rong Ji} and Deng, {Yu Lin} and Fang L{\"u}",

year = "2014",

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TY - JOUR

T1 - Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

AU - Liu, Fang

AU - Dai, Rong Ji

AU - Deng, Yu Lin

AU - Lü, Fang

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

AB - The anticancer activities of three stilbenes on melanoma HSC-1were studied. Trans-4', 5-dihydroxy-3-methoxy-diphenylthene, trans-4', 3, 5-trihydroxy-diphenylthene (resveratrol) shows significant inhibiting proliferation effects on HSC-1 in a concentration-and time-dependent manner except trans-4'-dihydroxy-3, 5-dimethoxy-diphenylthene (pterostilbene). The apoptosis of HSC-1 was significantly increased and the cell cycles were altered by the treatments of trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol with the concentration of IC50 by 72 h(p<0.001). The cell counts of G0/G1 increased obviously (p<0.001) and G0/G1, S, G2/M reduced (p<0.01). The results show that trans-4', 5-dihydroxy-3-methoxy-diphenylthene and resveratrol inhibit cancer cell growth in vitro via inducing apoptosis and blocking cell cycles.

KW - Activity

KW - Anticancer

KW - Dragon' blood

KW - Melanoma

KW - Stilbenes

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M3 - Article

AN - SCOPUS:84920087490

SN - 1001-0645

VL - 34

SP - 1090

EP - 1093

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 10

ER -

Anticancer activities in vitro of stilbenes from dragon's blood on melanoma HSC-1

Abstract

Keywords

UN SDGs

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