An improved synthesis of trantinterol

H. Wen; L. Qin; L. Pan; J. Li; M. Cheng

doi:10.1007/s11094-012-0788-y

An improved synthesis of trantinterol

H. Wen^*, L. Qin, L. Pan, J. Li, M. Cheng

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β₂ -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl₂ (dppf) as a key step.

Original language	English
Pages (from-to)	313-315
Number of pages	3
Journal	Pharmaceutical Chemistry Journal
Volume	46
Issue number	5
DOIs	https://doi.org/10.1007/s11094-012-0788-y
Publication status	Published - Aug 2012

Keywords

Palladium catalyzed carbonylation
Synthesis
Trantinterol

Access to Document

10.1007/s11094-012-0788-y

Cite this

@article{c2fd8f23cbf84d10bc636ac93c96b8f8,

title = "An improved synthesis of trantinterol",

abstract = "An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.",

keywords = "Palladium catalyzed carbonylation, Synthesis, Trantinterol",

author = "H. Wen and L. Qin and L. Pan and J. Li and M. Cheng",

year = "2012",

month = aug,

doi = "10.1007/s11094-012-0788-y",

language = "English",

volume = "46",

pages = "313--315",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

number = "5",

}

TY - JOUR

T1 - An improved synthesis of trantinterol

AU - Wen, H.

AU - Qin, L.

AU - Pan, L.

AU - Li, J.

AU - Cheng, M.

PY - 2012/8

Y1 - 2012/8

N2 - An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.

AB - An efficient synthesis of 2-(4-amino-3-chloro-5-trifluoromethylphenyl)-2-t- butylamino-ethanol (trantinterol), a selective β2 -adrenoceptor agonist, has been achieved from inexpensive and commercially available starting material. The synthesis involves the conversion of aryl iodide to aldehyde catalyzed by PdCl2 (dppf) as a key step.

KW - Palladium catalyzed carbonylation

KW - Synthesis

KW - Trantinterol

UR - http://www.scopus.com/inward/record.url?scp=85028103052&partnerID=8YFLogxK

U2 - 10.1007/s11094-012-0788-y

DO - 10.1007/s11094-012-0788-y

M3 - Article

AN - SCOPUS:85028103052

SN - 0091-150X

VL - 46

SP - 313

EP - 315

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 5

ER -

An improved synthesis of trantinterol

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this