Advances in probing single biomolecules: From DNA bases to glycans

Baofei Hou; Teng Zhang; Huixia Yang; Xu Han; Liwei Liu; Linfei Li; Cesare Grazioli; Xu Wu; Nan Jiang; Yeliang Wang

doi:10.1002/idm2.12106

Advances in probing single biomolecules: From DNA bases to glycans

Baofei Hou, Teng Zhang^*, Huixia Yang, Xu Han, Liwei Liu, Linfei Li, Cesare Grazioli, Xu Wu^*, Nan Jiang, Yeliang Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

Original language	English
Pages (from-to)	511-528
Number of pages	18
Journal	Interdisciplinary Materials
Volume	2
Issue number	4
DOIs	https://doi.org/10.1002/idm2.12106
Publication status	Published - Jul 2023

Keywords

atomic-scale probing
biomolecules
scanning probe microscopy
structure
visualization

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10.1002/idm2.12106

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Hou, B., Zhang, T., Yang, H., Han, X., Liu, L., Li, L., Grazioli, C., Wu, X., Jiang, N., & Wang, Y. (2023). Advances in probing single biomolecules: From DNA bases to glycans. Interdisciplinary Materials, 2(4), 511-528. https://doi.org/10.1002/idm2.12106

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abstract = "Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.",

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author = "Baofei Hou and Teng Zhang and Huixia Yang and Xu Han and Liwei Liu and Linfei Li and Cesare Grazioli and Xu Wu and Nan Jiang and Yeliang Wang",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Interdisciplinary Materials published by Wuhan University of Technology and John Wiley & Sons Australia, Ltd.",

year = "2023",

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doi = "10.1002/idm2.12106",

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AU - Han, Xu

AU - Liu, Liwei

AU - Li, Linfei

AU - Grazioli, Cesare

AU - Wu, Xu

AU - Jiang, Nan

AU - Wang, Yeliang

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N2 - Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

AB - Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

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Advances in probing single biomolecules: From DNA bases to glycans

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Keywords

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