A wireless optoelectronic probe to monitor oxygenation in deep brain tissue

Xue Cai; Haijian Zhang; Penghu Wei; Quanlei Liu; Dawid Sheng; Zhen Li; Bozhen Zhang; Guo Tang; Wenxin Zhao; Zhongyin Ye; Zhao Xue; Yang Xie; Yang Dai; Changming Wang; Yuqi Wang; Xin Fu; Lan Yin; Hongshang Peng; He Ding; Guoguang Zhao; Xing Sheng

doi:10.1038/s41566-023-01374-y

A wireless optoelectronic probe to monitor oxygenation in deep brain tissue

Xue Cai, Haijian Zhang, Penghu Wei, Quanlei Liu, Dawid Sheng, Zhen Li, Bozhen Zhang, Guo Tang, Wenxin Zhao, Zhongyin Ye, Zhao Xue, Yang Xie, Yang Dai, Changming Wang, Yuqi Wang, Xin Fu, Lan Yin, Hongshang Peng, He Ding^*, Guoguang Zhao^*Xing Sheng^*

^*Corresponding author for this work

School of Optics and Photonics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Real-time detection of tissue oxygenation in the nervous system is crucial in neuroscience studies and clinical diagnostics. Complementary to blood oxygenation levels, the partial pressure of oxygen in brain tissue (p_{_btO₂}) plays a key role in regulating local neural activities and metabolism. Here we develop an implantable optoelectronic probe that wirelessly and continuously monitors p_{_btO₂} signals in the deep brain of freely moving rodents. The thin-film, microscale implant integrates a light-emitting diode and a photodetector, and is coated with an oxygen-sensitive phosphorescent film. Powered by a battery or an inductive coil, a miniaturized circuit is capable of recording and wirelessly transmitting p_{_btO₂} signals. The wireless micro-probe captures cerebral hypoxia states in mice in various scenarios, including altered inspired oxygen concentrations and acute ischaemia. In mouse models with seizures, the micro-probe associates temporal p_{_btO₂} variations in multiple brain regions with electrical stimulations applied to the hippocampus. Our probe and method offer important insights into neuroscience studies regarding neurometabolic coupling and pave the way for the clinical application of implantable wireless optoelectronic probes.

Original language	English
Pages (from-to)	492-500
Number of pages	9
Journal	Nature Photonics
Volume	18
Issue number	5
DOIs	https://doi.org/10.1038/s41566-023-01374-y
Publication status	Published - May 2024

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title = "A wireless optoelectronic probe to monitor oxygenation in deep brain tissue",

abstract = "Real-time detection of tissue oxygenation in the nervous system is crucial in neuroscience studies and clinical diagnostics. Complementary to blood oxygenation levels, the partial pressure of oxygen in brain tissue (pbtO2) plays a key role in regulating local neural activities and metabolism. Here we develop an implantable optoelectronic probe that wirelessly and continuously monitors pbtO2 signals in the deep brain of freely moving rodents. The thin-film, microscale implant integrates a light-emitting diode and a photodetector, and is coated with an oxygen-sensitive phosphorescent film. Powered by a battery or an inductive coil, a miniaturized circuit is capable of recording and wirelessly transmitting pbtO2 signals. The wireless micro-probe captures cerebral hypoxia states in mice in various scenarios, including altered inspired oxygen concentrations and acute ischaemia. In mouse models with seizures, the micro-probe associates temporal pbtO2 variations in multiple brain regions with electrical stimulations applied to the hippocampus. Our probe and method offer important insights into neuroscience studies regarding neurometabolic coupling and pave the way for the clinical application of implantable wireless optoelectronic probes.",

author = "Xue Cai and Haijian Zhang and Penghu Wei and Quanlei Liu and Dawid Sheng and Zhen Li and Bozhen Zhang and Guo Tang and Wenxin Zhao and Zhongyin Ye and Zhao Xue and Yang Xie and Yang Dai and Changming Wang and Yuqi Wang and Xin Fu and Lan Yin and Hongshang Peng and He Ding and Guoguang Zhao and Xing Sheng",

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year = "2024",

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doi = "10.1038/s41566-023-01374-y",

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AU - Cai, Xue

AU - Zhang, Haijian

AU - Wei, Penghu

AU - Liu, Quanlei

AU - Sheng, Dawid

AU - Li, Zhen

AU - Zhang, Bozhen

AU - Tang, Guo

AU - Zhao, Wenxin

AU - Ye, Zhongyin

AU - Xue, Zhao

AU - Xie, Yang

AU - Dai, Yang

AU - Wang, Changming

AU - Wang, Yuqi

AU - Fu, Xin

AU - Yin, Lan

AU - Peng, Hongshang

AU - Ding, He

AU - Zhao, Guoguang

AU - Sheng, Xing

PY - 2024/5

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N2 - Real-time detection of tissue oxygenation in the nervous system is crucial in neuroscience studies and clinical diagnostics. Complementary to blood oxygenation levels, the partial pressure of oxygen in brain tissue (pbtO2) plays a key role in regulating local neural activities and metabolism. Here we develop an implantable optoelectronic probe that wirelessly and continuously monitors pbtO2 signals in the deep brain of freely moving rodents. The thin-film, microscale implant integrates a light-emitting diode and a photodetector, and is coated with an oxygen-sensitive phosphorescent film. Powered by a battery or an inductive coil, a miniaturized circuit is capable of recording and wirelessly transmitting pbtO2 signals. The wireless micro-probe captures cerebral hypoxia states in mice in various scenarios, including altered inspired oxygen concentrations and acute ischaemia. In mouse models with seizures, the micro-probe associates temporal pbtO2 variations in multiple brain regions with electrical stimulations applied to the hippocampus. Our probe and method offer important insights into neuroscience studies regarding neurometabolic coupling and pave the way for the clinical application of implantable wireless optoelectronic probes.

AB - Real-time detection of tissue oxygenation in the nervous system is crucial in neuroscience studies and clinical diagnostics. Complementary to blood oxygenation levels, the partial pressure of oxygen in brain tissue (pbtO2) plays a key role in regulating local neural activities and metabolism. Here we develop an implantable optoelectronic probe that wirelessly and continuously monitors pbtO2 signals in the deep brain of freely moving rodents. The thin-film, microscale implant integrates a light-emitting diode and a photodetector, and is coated with an oxygen-sensitive phosphorescent film. Powered by a battery or an inductive coil, a miniaturized circuit is capable of recording and wirelessly transmitting pbtO2 signals. The wireless micro-probe captures cerebral hypoxia states in mice in various scenarios, including altered inspired oxygen concentrations and acute ischaemia. In mouse models with seizures, the micro-probe associates temporal pbtO2 variations in multiple brain regions with electrical stimulations applied to the hippocampus. Our probe and method offer important insights into neuroscience studies regarding neurometabolic coupling and pave the way for the clinical application of implantable wireless optoelectronic probes.

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JO - Nature Photonics

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A wireless optoelectronic probe to monitor oxygenation in deep brain tissue

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