TY - JOUR
T1 - A recyclable tetracycline imprinted polymeric SPR sensor
T2 - In synergy with itaconic acid and methacrylic acid
AU - Nawaz, Tehseen
AU - Ahmad, Muhammad
AU - Yu, Jieying
AU - Wang, Shiqi
AU - Wei, Tianxin
N1 - Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2021.
PY - 2021/2/14
Y1 - 2021/2/14
N2 - A novel tetracycline (TC) imprinted polymer was prepared in visible lightviasynergy of dual functional group monomers methacrylic acid (MAA) and itaconic acid (IA) for the selective detection of TC in urine and milk samples. Surface plasmon resonance (SPR) and the reversible addition fragmentation chain transfer (RAFT) mechanism were employed in combination with 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid (CDTPA) in the presence of ethylene glycol dimethacrylate (EGDMA) as the cross-linker. In addition, the ratio of template, IA, MAA and EGDMA was optimized (0.8 : 0.3 : 5 : 9) by real time monitoringviaSPR. The surface of the TC imprinted sensor chip was characterized by contact angle measurements, Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The (IA-MAA@SPR)MIP sensor chip displayed a high adsorption capacity and selectivity in comparison to other analogues and non-imprinted polymer (NIP) based sensor chips. Through 7 adsorption-desorption cycles, the (IA-MAA@SPR)MIP sensor chip exhibited a good recoverability. These features suggested that the IA-MAA based sensor chip was an ideal candidate for the detection of TC. Consequently, within the concentration range of 1 × 10−13-1 × 10−7mol L−1, the reflectivity changesversusthe negative logarithm of concentrations presented excellent linearity;R2= 0.99. Based on a linear equation, the IA-MAA@SPR MIP sensor chip showed lower values for the limit of detection (LOD) and limit of quantification (LOQ)i.e.1.38 × 10−14mol L−1and 4.5 × 10−14mol L−1, respectively. Furthermore, the influence of the matrix on the sensor chip was successfully analyzed in real samples with satisfactory outcomes. Hence, IA-MAA based MIPs in combination with the SPR sensor chip demonstrated potential application prospects for rapid and effective sensing even in the complicated matrices.
AB - A novel tetracycline (TC) imprinted polymer was prepared in visible lightviasynergy of dual functional group monomers methacrylic acid (MAA) and itaconic acid (IA) for the selective detection of TC in urine and milk samples. Surface plasmon resonance (SPR) and the reversible addition fragmentation chain transfer (RAFT) mechanism were employed in combination with 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid (CDTPA) in the presence of ethylene glycol dimethacrylate (EGDMA) as the cross-linker. In addition, the ratio of template, IA, MAA and EGDMA was optimized (0.8 : 0.3 : 5 : 9) by real time monitoringviaSPR. The surface of the TC imprinted sensor chip was characterized by contact angle measurements, Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The (IA-MAA@SPR)MIP sensor chip displayed a high adsorption capacity and selectivity in comparison to other analogues and non-imprinted polymer (NIP) based sensor chips. Through 7 adsorption-desorption cycles, the (IA-MAA@SPR)MIP sensor chip exhibited a good recoverability. These features suggested that the IA-MAA based sensor chip was an ideal candidate for the detection of TC. Consequently, within the concentration range of 1 × 10−13-1 × 10−7mol L−1, the reflectivity changesversusthe negative logarithm of concentrations presented excellent linearity;R2= 0.99. Based on a linear equation, the IA-MAA@SPR MIP sensor chip showed lower values for the limit of detection (LOD) and limit of quantification (LOQ)i.e.1.38 × 10−14mol L−1and 4.5 × 10−14mol L−1, respectively. Furthermore, the influence of the matrix on the sensor chip was successfully analyzed in real samples with satisfactory outcomes. Hence, IA-MAA based MIPs in combination with the SPR sensor chip demonstrated potential application prospects for rapid and effective sensing even in the complicated matrices.
UR - http://www.scopus.com/inward/record.url?scp=85101445880&partnerID=8YFLogxK
U2 - 10.1039/d0nj05364c
DO - 10.1039/d0nj05364c
M3 - Article
AN - SCOPUS:85101445880
SN - 1144-0546
VL - 45
SP - 3102
EP - 3111
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 6
ER -
