A predictive model for the release of slightly water-soluble drugs from HPMC matrices

Xuchun C. Fu; G. P. Wang; Y. H. Wang; W. Q. Liang

A predictive model for the release of slightly water-soluble drugs from HPMC matrices

Xuchun C. Fu^*, G. P. Wang, Y. H. Wang, W. Q. Liang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A model to predict the fraction of slightly water-soluble drug released as a function of release time (t, h), HPMC concentration (C_H, w/w), drug solubility in distilled water at 37 °C (C_s, g/100 mL), and volume of drug molecule (V, nm³) was derived when theophyline, tinidazole, and propylthiouracil were selected as model drugs. The model is log (M_tM∞) = 0.8683 logt-0.1930C_s logt + 0.5406V logt-1.227C_H + 0.1594C_s + 0.4423C_HC_S - 0.8655 (n = 130, r = 0.9969), where Mt is the amount of drug released at time t, M∞ is the amount of drug released over a very long time, which corresponds in principle to the initial loading, n is the number of samples, and r is the correlation coefficient. The model was validated using sulfamethoxazole and satisfactory results were obtained. The model can be used to predict the release fraction of various slightly water-soluble drugs from HPMC matrices having different polymer levels.

Original language	English
Pages (from-to)	624-626
Number of pages	3
Journal	Die Pharmazie
Volume	59
Issue number	8
Publication status	Published - Aug 2004
Externally published	Yes

Cite this

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title = "A predictive model for the release of slightly water-soluble drugs from HPMC matrices",

abstract = "A model to predict the fraction of slightly water-soluble drug released as a function of release time (t, h), HPMC concentration (CH, w/w), drug solubility in distilled water at 37 °C (Cs, g/100 mL), and volume of drug molecule (V, nm3) was derived when theophyline, tinidazole, and propylthiouracil were selected as model drugs. The model is log (MtM∞) = 0.8683 logt-0.1930Cs logt + 0.5406V logt-1.227CH + 0.1594Cs + 0.4423CHCS - 0.8655 (n = 130, r = 0.9969), where Mt is the amount of drug released at time t, M∞ is the amount of drug released over a very long time, which corresponds in principle to the initial loading, n is the number of samples, and r is the correlation coefficient. The model was validated using sulfamethoxazole and satisfactory results were obtained. The model can be used to predict the release fraction of various slightly water-soluble drugs from HPMC matrices having different polymer levels.",

author = "Fu, {Xuchun C.} and Wang, {G. P.} and Wang, {Y. H.} and Liang, {W. Q.}",

year = "2004",

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language = "English",

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AU - Wang, G. P.

AU - Wang, Y. H.

AU - Liang, W. Q.

PY - 2004/8

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N2 - A model to predict the fraction of slightly water-soluble drug released as a function of release time (t, h), HPMC concentration (CH, w/w), drug solubility in distilled water at 37 °C (Cs, g/100 mL), and volume of drug molecule (V, nm3) was derived when theophyline, tinidazole, and propylthiouracil were selected as model drugs. The model is log (MtM∞) = 0.8683 logt-0.1930Cs logt + 0.5406V logt-1.227CH + 0.1594Cs + 0.4423CHCS - 0.8655 (n = 130, r = 0.9969), where Mt is the amount of drug released at time t, M∞ is the amount of drug released over a very long time, which corresponds in principle to the initial loading, n is the number of samples, and r is the correlation coefficient. The model was validated using sulfamethoxazole and satisfactory results were obtained. The model can be used to predict the release fraction of various slightly water-soluble drugs from HPMC matrices having different polymer levels.

AB - A model to predict the fraction of slightly water-soluble drug released as a function of release time (t, h), HPMC concentration (CH, w/w), drug solubility in distilled water at 37 °C (Cs, g/100 mL), and volume of drug molecule (V, nm3) was derived when theophyline, tinidazole, and propylthiouracil were selected as model drugs. The model is log (MtM∞) = 0.8683 logt-0.1930Cs logt + 0.5406V logt-1.227CH + 0.1594Cs + 0.4423CHCS - 0.8655 (n = 130, r = 0.9969), where Mt is the amount of drug released at time t, M∞ is the amount of drug released over a very long time, which corresponds in principle to the initial loading, n is the number of samples, and r is the correlation coefficient. The model was validated using sulfamethoxazole and satisfactory results were obtained. The model can be used to predict the release fraction of various slightly water-soluble drugs from HPMC matrices having different polymer levels.

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JF - Die Pharmazie

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A predictive model for the release of slightly water-soluble drugs from HPMC matrices

Abstract

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