A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach

Kan Lin, Mads Sylvest Bergholt, Jianfeng Wang, Wei Zheng, Hongzhi Xu, Jian Lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report a novel simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman spectroscopy developed for in vivo diagnosis of intestinal metaplasia (IM) in the stomach under wide-field endoscopic imaging. The FP/HW Raman endoscopy technique was performed to differentiate IM from normal tissues with sensitivity of 89% and specificity of 83%. This study shows the great potential of the FP/HW Raman endoscopic technique for early diagnosis of non-neoplastic gastric disease in vivo during routine endoscopic examination.

Original languageEnglish
Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
EditorsAnita Mahadevan-Jansen, Tuan Vo-Dinh, Warren S. Grundfest
PublisherSPIE
ISBN (Electronic)9781628414035
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII - San Francisco, United States
Duration: 8 Feb 201510 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9313
ISSN (Print)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Country/TerritoryUnited States
CitySan Francisco
Period8/02/1510/02/15

Keywords

  • Raman spectroscopy
  • endoscopy
  • fingerprint
  • gastric intestinal metaplasia
  • high-wavenumber

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