TY - GEN
T1 - A new vision for biomedicine
T2 - 6th International Conference on Complex Medical Engineering, CME 2012
AU - Gomez-Ramirez, Jaime
AU - Wu, Jinglong
PY - 2012
Y1 - 2012
N2 - While it is widely recognised that, on the one hand, reductionistic approaches are inadequate to deal with the multifactorial and complex nature of health and disease, and on the other hand, a system level understanding of the normal and pathological functioning of biological systems is sorely needed; no clear procedure have been put forth about the actual implementation of such a program. In this paper we review the tools and the mode of thinking that systems biology has set forward in the last twenty years, pinpointing its key methodological and epistemic aspects, together with the technical obstacles and conceptual limitations that it is faced with. A new approach conducive to a system level understanding of biomedical systems is thus, proposed.
AB - While it is widely recognised that, on the one hand, reductionistic approaches are inadequate to deal with the multifactorial and complex nature of health and disease, and on the other hand, a system level understanding of the normal and pathological functioning of biological systems is sorely needed; no clear procedure have been put forth about the actual implementation of such a program. In this paper we review the tools and the mode of thinking that systems biology has set forward in the last twenty years, pinpointing its key methodological and epistemic aspects, together with the technical obstacles and conceptual limitations that it is faced with. A new approach conducive to a system level understanding of biomedical systems is thus, proposed.
KW - adaptation
KW - category theory
KW - robustness
KW - stability
KW - systems biology
UR - http://www.scopus.com/inward/record.url?scp=84867628825&partnerID=8YFLogxK
U2 - 10.1109/ICCME.2012.6275702
DO - 10.1109/ICCME.2012.6275702
M3 - Conference contribution
AN - SCOPUS:84867628825
SN - 9781467316163
T3 - 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings
SP - 479
EP - 484
BT - 2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings
Y2 - 1 July 2012 through 4 July 2012
ER -