A monolithically integrated platform for high throughput cell characterization and drug screening

Xu Ji; Lin Yang; Zewen Wei; Lu Wang; Jianzhong Xi; Zhihong Li

doi:10.1109/SENSOR.2009.5285720

A monolithically integrated platform for high throughput cell characterization and drug screening

Xu Ji, Lin Yang, Zewen Wei, Lu Wang, Jianzhong Xi, Zhihong Li^*

^*Corresponding author for this work

Peking University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Real-time physiological properties' characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells self-assembled on the surface directed by the gold pattern. Preliminary experiment validates feasibility of the procedure. Finally, chip-level packaging is performed using a PDMS cap and a plastic tube.

Original language	English
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	1786-1789
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285720
Publication status	Published - 2009
Externally published	Yes
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: 21 Jun 2009 → 25 Jun 2009

Publication series

Name	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country/Territory	United States
City	Denver, CO
Period	21/06/09 → 25/06/09

Keywords

Cell characterization
Drug screening
Monolithical integration
Self-assembly

Access to Document

10.1109/SENSOR.2009.5285720

Cite this

Ji, X., Yang, L., Wei, Z., Wang, L., Xi, J., & Li, Z. (2009). A monolithically integrated platform for high throughput cell characterization and drug screening. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1786-1789). Article 5285720 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285720

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title = "A monolithically integrated platform for high throughput cell characterization and drug screening",

abstract = "Real-time physiological properties' characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells self-assembled on the surface directed by the gold pattern. Preliminary experiment validates feasibility of the procedure. Finally, chip-level packaging is performed using a PDMS cap and a plastic tube.",

keywords = "Cell characterization, Drug screening, Monolithical integration, Self-assembly",

author = "Xu Ji and Lin Yang and Zewen Wei and Lu Wang and Jianzhong Xi and Zhihong Li",

year = "2009",

doi = "10.1109/SENSOR.2009.5285720",

language = "English",

isbn = "9781424441938",

series = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

pages = "1786--1789",

booktitle = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems",

note = "TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems ; Conference date: 21-06-2009 Through 25-06-2009",

}

Ji, X, Yang, L, Wei, Z, Wang, L, Xi, J & Li, Z 2009, A monolithically integrated platform for high throughput cell characterization and drug screening. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285720, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 1786-1789, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 21/06/09. https://doi.org/10.1109/SENSOR.2009.5285720

A monolithically integrated platform for high throughput cell characterization and drug screening. / Ji, Xu; Yang, Lin; Wei, Zewen et al.
TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 1786-1789 5285720 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A monolithically integrated platform for high throughput cell characterization and drug screening

AU - Ji, Xu

AU - Yang, Lin

AU - Wei, Zewen

AU - Wang, Lu

AU - Xi, Jianzhong

AU - Li, Zhihong

PY - 2009

Y1 - 2009

N2 - Real-time physiological properties' characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells self-assembled on the surface directed by the gold pattern. Preliminary experiment validates feasibility of the procedure. Finally, chip-level packaging is performed using a PDMS cap and a plastic tube.

AB - Real-time physiological properties' characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells self-assembled on the surface directed by the gold pattern. Preliminary experiment validates feasibility of the procedure. Finally, chip-level packaging is performed using a PDMS cap and a plastic tube.

KW - Cell characterization

KW - Drug screening

KW - Monolithical integration

KW - Self-assembly

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U2 - 10.1109/SENSOR.2009.5285720

DO - 10.1109/SENSOR.2009.5285720

M3 - Conference contribution

AN - SCOPUS:71449126749

SN - 9781424441938

T3 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

SP - 1786

EP - 1789

BT - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

T2 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Y2 - 21 June 2009 through 25 June 2009

ER -

Ji X, Yang L, Wei Z, Wang L, Xi J, Li Z. A monolithically integrated platform for high throughput cell characterization and drug screening. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 1786-1789. 5285720. (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2009.5285720

A monolithically integrated platform for high throughput cell characterization and drug screening

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Keywords

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