A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells

Masahiro Totani; Masaru Kojima; Mitsuhiro Horade; Kazuto Kamiyama; Yasushi Mae; Toshihiko Ogura; Makoto Kaneko; Tatsuo Arai

doi:10.1109/MHS.2016.7824190

A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells

Masahiro Totani, Masaru Kojima, Mitsuhiro Horade, Kazuto Kamiyama, Yasushi Mae, Toshihiko Ogura, Makoto Kaneko, Tatsuo Arai

Osaka University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Many researches have reported that the mechanical stimulus is important factor of the histogenesis and cellular differentiation. However, it is not clearly understood for cellular nucleus how to respond to the mechanical stimulus. Our purpose is applying a mechanical stimulus to cells for gene expression assay. On this paper, we report development of a micro-channel device and evaluating the device by observation. This device is designed to have a low-height channel and cells are pressed when passing through that channel. In experiment, we succeed in observing that cells and nucleuses are deformed in the channel. In addition, 2.0 × 10⁴ cells are collected from this device.

Original language	English
Title of host publication	2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509027842
DOIs	https://doi.org/10.1109/MHS.2016.7824190
Publication status	Published - 18 Jan 2017
Externally published	Yes
Event	27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 - Nagoya, Japan Duration: 28 Nov 2016 → 30 Nov 2016

Publication series

Name	2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016

Conference

Conference	27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
Country/Territory	Japan
City	Nagoya
Period	28/11/16 → 30/11/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MHS.2016.7824190

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Totani, M., Kojima, M., Horade, M., Kamiyama, K., Mae, Y., Ogura, T., Kaneko, M., & Arai, T. (2017). A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. In 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 Article 7824190 (2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2016.7824190

Totani, Masahiro ; Kojima, Masaru ; Horade, Mitsuhiro et al. / A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc., 2017. (2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016).

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title = "A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells",

abstract = "Many researches have reported that the mechanical stimulus is important factor of the histogenesis and cellular differentiation. However, it is not clearly understood for cellular nucleus how to respond to the mechanical stimulus. Our purpose is applying a mechanical stimulus to cells for gene expression assay. On this paper, we report development of a micro-channel device and evaluating the device by observation. This device is designed to have a low-height channel and cells are pressed when passing through that channel. In experiment, we succeed in observing that cells and nucleuses are deformed in the channel. In addition, 2.0 × 104 cells are collected from this device.",

author = "Masahiro Totani and Masaru Kojima and Mitsuhiro Horade and Kazuto Kamiyama and Yasushi Mae and Toshihiko Ogura and Makoto Kaneko and Tatsuo Arai",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 ; Conference date: 28-11-2016 Through 30-11-2016",

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doi = "10.1109/MHS.2016.7824190",

language = "English",

series = "2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016",

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Totani, M, Kojima, M, Horade, M, Kamiyama, K, Mae, Y, Ogura, T, Kaneko, M & Arai, T 2017, A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. in 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016., 7824190, 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016, Institute of Electrical and Electronics Engineers Inc., 27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016, Nagoya, Japan, 28/11/16. https://doi.org/10.1109/MHS.2016.7824190

A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. / Totani, Masahiro; Kojima, Masaru; Horade, Mitsuhiro et al.
2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc., 2017. 7824190 (2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells

AU - Totani, Masahiro

AU - Kojima, Masaru

AU - Horade, Mitsuhiro

AU - Kamiyama, Kazuto

AU - Mae, Yasushi

AU - Ogura, Toshihiko

AU - Kaneko, Makoto

AU - Arai, Tatsuo

PY - 2017/1/18

Y1 - 2017/1/18

N2 - Many researches have reported that the mechanical stimulus is important factor of the histogenesis and cellular differentiation. However, it is not clearly understood for cellular nucleus how to respond to the mechanical stimulus. Our purpose is applying a mechanical stimulus to cells for gene expression assay. On this paper, we report development of a micro-channel device and evaluating the device by observation. This device is designed to have a low-height channel and cells are pressed when passing through that channel. In experiment, we succeed in observing that cells and nucleuses are deformed in the channel. In addition, 2.0 × 104 cells are collected from this device.

AB - Many researches have reported that the mechanical stimulus is important factor of the histogenesis and cellular differentiation. However, it is not clearly understood for cellular nucleus how to respond to the mechanical stimulus. Our purpose is applying a mechanical stimulus to cells for gene expression assay. On this paper, we report development of a micro-channel device and evaluating the device by observation. This device is designed to have a low-height channel and cells are pressed when passing through that channel. In experiment, we succeed in observing that cells and nucleuses are deformed in the channel. In addition, 2.0 × 104 cells are collected from this device.

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M3 - Conference contribution

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T3 - 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016

BT - 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016

PB - Institute of Electrical and Electronics Engineers Inc.

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Totani M, Kojima M, Horade M, Kamiyama K, Mae Y, Ogura T et al. A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells. In 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc. 2017. 7824190. (2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016). doi: 10.1109/MHS.2016.7824190

A micro channel device for biomechanical analysis to apply a mechanical stimulus on large number of cells

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