Deng, Y., Qi, H., Ma, Y., Liu, S., Zhao, M., Guo, Z., Jie, Y., Zheng, R., Jing, J., Chen, K., Ding, H., Lv, G., Zhang, K., Li, R., Cheng, H., Zhao, L., Sheng, X., Zhang, M., & Yin, L. (2022). A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection. Proceedings of the National Academy of Sciences of the United States of America, 119(34), Article e2208060119. https://doi.org/10.1073/pnas.2208060119
Deng, Yuping ; Qi, Hui ; Ma, Yuan et al. / A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection. In: Proceedings of the National Academy of Sciences of the United States of America. 2022 ; Vol. 119, No. 34.
@article{f2234491c5104c6e8ee77d21c66149a0,
title = "A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection",
abstract = "As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection of NO in live organisms is in great demand. Traditional assessments of NO rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials and can hardly satisfy sensitivity and spatial resolution simultaneously. Here, we report a flexible and highly sensitive biosensor based on organic electrochemical transistors (OECTs) capable of continuous and wireless detection of NO in biological systems. By modifying the geometry of the active channel and the gate electrodes of OECTs, devices achieve optimum signal amplification of NO. The sensor exhibits a low response limit, a wide linear range, high sensitivity, and excellent selectivity, with a miniaturized active sensing region compared with a conventional electrochemical sensor. The device demonstrates continuous detection of the nanomolar range of NO in cultured cells for hours without significant signal drift. Real-time and wireless measurement of NO is accomplished for 8 d in the articular cavity of New Zealand White rabbits with anterior cruciate ligament (ACL) rupture injuries. The observed high level of NO is associated with the onset of osteoarthritis (OA) at the later stage. The proposed device platform could provide critical information for the early diagnosis of chronic diseases and timely medical intervention to optimize therapeutic efficacy.",
keywords = "flexible electronics, nitric oxide sensor, organic electrochemical transistor, osteoarthritis",
author = "Yuping Deng and Hui Qi and Yuan Ma and Shangbin Liu and Mingyou Zhao and Zhenhu Guo and Yongsheng Jie and Rui Zheng and Jinzhu Jing and Kuntao Chen and He Ding and Guoqing Lv and Kaiyuan Zhang and Rongfeng Li and Huanyu Cheng and Lingyun Zhao and Xing Sheng and Milin Zhang and Lan Yin",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 the Author(s). Published by PNAS.",
year = "2022",
month = aug,
day = "23",
doi = "10.1073/pnas.2208060119",
language = "English",
volume = "119",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "34",
}
Deng, Y, Qi, H, Ma, Y, Liu, S, Zhao, M, Guo, Z, Jie, Y, Zheng, R, Jing, J, Chen, K, Ding, H, Lv, G, Zhang, K, Li, R, Cheng, H, Zhao, L, Sheng, X, Zhang, M & Yin, L 2022, 'A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 34, e2208060119. https://doi.org/10.1073/pnas.2208060119
A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection. / Deng, Yuping; Qi, Hui; Ma, Yuan et al.
In:
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 34, e2208060119, 23.08.2022.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection
AU - Deng, Yuping
AU - Qi, Hui
AU - Ma, Yuan
AU - Liu, Shangbin
AU - Zhao, Mingyou
AU - Guo, Zhenhu
AU - Jie, Yongsheng
AU - Zheng, Rui
AU - Jing, Jinzhu
AU - Chen, Kuntao
AU - Ding, He
AU - Lv, Guoqing
AU - Zhang, Kaiyuan
AU - Li, Rongfeng
AU - Cheng, Huanyu
AU - Zhao, Lingyun
AU - Sheng, Xing
AU - Zhang, Milin
AU - Yin, Lan
N1 - Publisher Copyright:
Copyright © 2022 the Author(s). Published by PNAS.
PY - 2022/8/23
Y1 - 2022/8/23
N2 - As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection of NO in live organisms is in great demand. Traditional assessments of NO rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials and can hardly satisfy sensitivity and spatial resolution simultaneously. Here, we report a flexible and highly sensitive biosensor based on organic electrochemical transistors (OECTs) capable of continuous and wireless detection of NO in biological systems. By modifying the geometry of the active channel and the gate electrodes of OECTs, devices achieve optimum signal amplification of NO. The sensor exhibits a low response limit, a wide linear range, high sensitivity, and excellent selectivity, with a miniaturized active sensing region compared with a conventional electrochemical sensor. The device demonstrates continuous detection of the nanomolar range of NO in cultured cells for hours without significant signal drift. Real-time and wireless measurement of NO is accomplished for 8 d in the articular cavity of New Zealand White rabbits with anterior cruciate ligament (ACL) rupture injuries. The observed high level of NO is associated with the onset of osteoarthritis (OA) at the later stage. The proposed device platform could provide critical information for the early diagnosis of chronic diseases and timely medical intervention to optimize therapeutic efficacy.
AB - As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection of NO in live organisms is in great demand. Traditional assessments of NO rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials and can hardly satisfy sensitivity and spatial resolution simultaneously. Here, we report a flexible and highly sensitive biosensor based on organic electrochemical transistors (OECTs) capable of continuous and wireless detection of NO in biological systems. By modifying the geometry of the active channel and the gate electrodes of OECTs, devices achieve optimum signal amplification of NO. The sensor exhibits a low response limit, a wide linear range, high sensitivity, and excellent selectivity, with a miniaturized active sensing region compared with a conventional electrochemical sensor. The device demonstrates continuous detection of the nanomolar range of NO in cultured cells for hours without significant signal drift. Real-time and wireless measurement of NO is accomplished for 8 d in the articular cavity of New Zealand White rabbits with anterior cruciate ligament (ACL) rupture injuries. The observed high level of NO is associated with the onset of osteoarthritis (OA) at the later stage. The proposed device platform could provide critical information for the early diagnosis of chronic diseases and timely medical intervention to optimize therapeutic efficacy.
KW - flexible electronics
KW - nitric oxide sensor
KW - organic electrochemical transistor
KW - osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=85136908928&partnerID=8YFLogxK
U2 - 10.1073/pnas.2208060119
DO - 10.1073/pnas.2208060119
M3 - Article
C2 - 35972962
AN - SCOPUS:85136908928
SN - 0027-8424
VL - 119
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 34
M1 - e2208060119
ER -
Deng Y, Qi H, Ma Y, Liu S, Zhao M, Guo Z et al. A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection. Proceedings of the National Academy of Sciences of the United States of America. 2022 Aug 23;119(34):e2208060119. doi: 10.1073/pnas.2208060119