A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Rahul T. Kadakia; Da Xie; Daniel Martinez; Meng Yu; Emily L. Que

doi:10.1039/c9cc00375d

A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence

Rahul T. Kadakia, Da Xie, Daniel Martinez, Meng Yu, Emily L. Que^*

^*Corresponding author for this work

Department of Chemistry, University of Texas at Austin

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We report the first dual-responsive ¹⁹F MRI and fluorescence imaging probe for cellular hypoxia. The Cu²⁺-based probe exhibits no ¹⁹F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu⁺. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

Original language	English
Pages (from-to)	8860-8863
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	60
DOIs	https://doi.org/10.1039/c9cc00375d
Publication status	Published - 2019
Externally published	Yes

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Kadakia, R. T., Xie, D., Martinez, D., Yu, M., & Que, E. L. (2019). A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence. Chemical Communications, 55(60), 8860-8863. https://doi.org/10.1039/c9cc00375d

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abstract = "We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.",

author = "Kadakia, {Rahul T.} and Da Xie and Daniel Martinez and Meng Yu and Que, {Emily L.}",

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AU - Kadakia, Rahul T.

AU - Xie, Da

AU - Martinez, Daniel

AU - Yu, Meng

AU - Que, Emily L.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2019.

PY - 2019

Y1 - 2019

N2 - We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

AB - We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

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U2 - 10.1039/c9cc00375d

DO - 10.1039/c9cc00375d

M3 - Article

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SN - 1359-7345

VL - 55

SP - 8860

EP - 8863

JO - Chemical Communications

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A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence

Abstract

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