A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles

Guang Long Wu; Qin Pei Wu

doi:10.1002/slct.201800669

A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles

Guang Long Wu, Qin Pei Wu^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A one-pot mild and metal-free procedure for efficient synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles has been developed through the sequentially reaction of pyridinium salts with aldehydes and sodium azide. In the presence of L-proline, a key intermediate, an olefinic pyridinium-salt, is in situ generated via coupling of pyridinium salts with aldehydes and cyclizes with azide ion to form a triazole ring.

Original language	English
Pages (from-to)	5212-5215
Number of pages	4
Journal	ChemistrySelect
Volume	3
Issue number	18
DOIs	https://doi.org/10.1002/slct.201800669
Publication status	Published - 15 May 2018

Keywords

cycloaddition
domino reaction
organocatalysis
pyridine
triazole

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10.1002/slct.201800669

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Wu, G. L., & Wu, Q. P. (2018). A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles. ChemistrySelect, 3(18), 5212-5215. https://doi.org/10.1002/slct.201800669

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AB - A one-pot mild and metal-free procedure for efficient synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles has been developed through the sequentially reaction of pyridinium salts with aldehydes and sodium azide. In the presence of L-proline, a key intermediate, an olefinic pyridinium-salt, is in situ generated via coupling of pyridinium salts with aldehydes and cyclizes with azide ion to form a triazole ring.

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KW - organocatalysis

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ER -

A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles

Abstract

Keywords

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