Ren, Q., Zhang, P., Pang, W., Ma, Y., Gong, S., Ba, T., Liu, W., Zhang, F., Zhang, X., Zhang, R., Wang, X., Zhang, X., Yang, W., Lv, F., Gao, L., Han, X., & Ji, L. (2023). A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology. Diabetes, 72(6), 812-818. https://doi.org/10.2337/db22-0566
Ren, Qian ; Zhang, Ping ; Pang, Wuyan et al. / A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology. In: Diabetes. 2023 ; Vol. 72, No. 6. pp. 812-818.
@article{e8692b1a2f9c41ef9e3db82098354b34,
title = "A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology",
abstract = "Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits the unique clinical features of mild fasting hyperglycemia. However, formal studies of its glucose excursion pattern in daily life in comparison with those with or without other types of diabetes are lacking. We conducted a case-control study including 25 patients with GCK-MODY, 25 A1C-matched, drugnaive patients with type 2 diabetes (T2DM), and 25 age-, BMI-, and sex-matched subjects with normal glucose tolerance (NGT). All the subjects wore flash glucose monitoring (FGM) sensors for 2 weeks, and glucose readings were masked. Glucose excursion was significantly lower in the GCK-MODY than that in A1C-matched T2DM during the daytime, but was similar during the nighttime. The daytime coefficient of variation (CV) driven by postprandial glucose could separate GCK-MODY from well-controlled T2DM, but the nighttime CV could not. In discriminating between GCK-MODY and T2DM, the area under the curve of the CV was 0.875. However, in GCK-MODY and NGT subjects, the CVs were similar at 24 h, whereas the other four excursion parameters were significantly higher in GCK-MODY than those in NGT subjects. FGM confirmed the stability and mildness of hyperglycemia in GCK-MODY patients. Postprandial regulation is a key driver of the difference in excursion between GCK-MODY and T2DM.",
author = "Qian Ren and Ping Zhang and Wuyan Pang and Yumin Ma and Siqian Gong and Tianhao Ba and Wei Liu and Fang Zhang and Xiuying Zhang and Rui Zhang and Xiangqing Wang and Xiaomei Zhang and Wenjia Yang and Fang Lv and Leili Gao and Xueyao Han and Linong Ji",
note = "Publisher Copyright: {\textcopyright} 2023 by the American Diabetes Association.",
year = "2023",
month = jun,
doi = "10.2337/db22-0566",
language = "English",
volume = "72",
pages = "812--818",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "6",
}
Ren, Q, Zhang, P, Pang, W, Ma, Y, Gong, S, Ba, T, Liu, W, Zhang, F, Zhang, X, Zhang, R, Wang, X, Zhang, X, Yang, W, Lv, F, Gao, L, Han, X & Ji, L 2023, 'A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology', Diabetes, vol. 72, no. 6, pp. 812-818. https://doi.org/10.2337/db22-0566
A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology. / Ren, Qian; Zhang, Ping; Pang, Wuyan et al.
In:
Diabetes, Vol. 72, No. 6, 06.2023, p. 812-818.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology
AU - Ren, Qian
AU - Zhang, Ping
AU - Pang, Wuyan
AU - Ma, Yumin
AU - Gong, Siqian
AU - Ba, Tianhao
AU - Liu, Wei
AU - Zhang, Fang
AU - Zhang, Xiuying
AU - Zhang, Rui
AU - Wang, Xiangqing
AU - Zhang, Xiaomei
AU - Yang, Wenjia
AU - Lv, Fang
AU - Gao, Leili
AU - Han, Xueyao
AU - Ji, Linong
N1 - Publisher Copyright:
© 2023 by the American Diabetes Association.
PY - 2023/6
Y1 - 2023/6
N2 - Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits the unique clinical features of mild fasting hyperglycemia. However, formal studies of its glucose excursion pattern in daily life in comparison with those with or without other types of diabetes are lacking. We conducted a case-control study including 25 patients with GCK-MODY, 25 A1C-matched, drugnaive patients with type 2 diabetes (T2DM), and 25 age-, BMI-, and sex-matched subjects with normal glucose tolerance (NGT). All the subjects wore flash glucose monitoring (FGM) sensors for 2 weeks, and glucose readings were masked. Glucose excursion was significantly lower in the GCK-MODY than that in A1C-matched T2DM during the daytime, but was similar during the nighttime. The daytime coefficient of variation (CV) driven by postprandial glucose could separate GCK-MODY from well-controlled T2DM, but the nighttime CV could not. In discriminating between GCK-MODY and T2DM, the area under the curve of the CV was 0.875. However, in GCK-MODY and NGT subjects, the CVs were similar at 24 h, whereas the other four excursion parameters were significantly higher in GCK-MODY than those in NGT subjects. FGM confirmed the stability and mildness of hyperglycemia in GCK-MODY patients. Postprandial regulation is a key driver of the difference in excursion between GCK-MODY and T2DM.
AB - Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits the unique clinical features of mild fasting hyperglycemia. However, formal studies of its glucose excursion pattern in daily life in comparison with those with or without other types of diabetes are lacking. We conducted a case-control study including 25 patients with GCK-MODY, 25 A1C-matched, drugnaive patients with type 2 diabetes (T2DM), and 25 age-, BMI-, and sex-matched subjects with normal glucose tolerance (NGT). All the subjects wore flash glucose monitoring (FGM) sensors for 2 weeks, and glucose readings were masked. Glucose excursion was significantly lower in the GCK-MODY than that in A1C-matched T2DM during the daytime, but was similar during the nighttime. The daytime coefficient of variation (CV) driven by postprandial glucose could separate GCK-MODY from well-controlled T2DM, but the nighttime CV could not. In discriminating between GCK-MODY and T2DM, the area under the curve of the CV was 0.875. However, in GCK-MODY and NGT subjects, the CVs were similar at 24 h, whereas the other four excursion parameters were significantly higher in GCK-MODY than those in NGT subjects. FGM confirmed the stability and mildness of hyperglycemia in GCK-MODY patients. Postprandial regulation is a key driver of the difference in excursion between GCK-MODY and T2DM.
UR - http://www.scopus.com/inward/record.url?scp=85159759687&partnerID=8YFLogxK
U2 - 10.2337/db22-0566
DO - 10.2337/db22-0566
M3 - Article
C2 - 36939643
AN - SCOPUS:85159759687
SN - 0012-1797
VL - 72
SP - 812
EP - 818
JO - Diabetes
JF - Diabetes
IS - 6
ER -
Ren Q, Zhang P, Pang W, Ma Y, Gong S, Ba T et al. A Comparison of Daily Glucose Fluctuation Between GCK-MODY and Type 2 Diabetes Using Continuous Glucose Monitoring Technology. Diabetes. 2023 Jun;72(6):812-818. doi: 10.2337/db22-0566
