胞内生物传感器提高微生物细胞工厂的精细调控

Under the background of advocating the green manufacturing of compounds, the use of microbial cell factories to synthesize new compounds or increase the yield of compounds is one of the important directions for the development of green chemical technology. However, the low yield of target compounds is a common problem in the synthesis of microbial cell factories. One of the effective ways to solve this bottleneck is to design biosensors in microbial cells to monitor and regulate the biosynthesis of compounds. This paper introduces the types and mechanism of intracellular biosensors in details, focusing on how biosensors are coupled with the design of product synthesis pathways in microbial cell factories to improve the fine regulation of cell factories and the ability to synthesize target products. Finally, the challenges and feasible solutions of the current intracellular biosensor design are discussed.