用于N-糖肽/糖蛋白分离富集的新型材料

Protein glycosylation plays a crucial role in regulating various complex biological processes, such as molecular recognition, immune response, and protein folding. Since glycopeptides/glycoproteins are less abundant in complex biological samples or clinical samples, separation and enrichment of target proteins are often required before glycoproteomics analysis. Research and development of novel materials with high-efficiency glycoprotein separation and enrichment ability are of great significance for the study of glycoprotein/glycopeptide. In recent years, many new glycoprotein separation and enrichment materials have been reported, such as organic polymer materials, bio-based materials, new organic framework materials and new functional composite materials. Due to their structure, biocompatibility and physical and chemical properties, these materials have promoted the development of glycoprotein separation and enrichment technology from different levels. In this paper, the new materials related to the separation and enrichment of glycopeptide/glycoprotein at home and abroad are summarized and discussed, and the future development is proposed.