四丁基溴化铵催化炔基酮的氢化反应

Propargyl alcohol compounds have many applications in medicine, pesticides and functional molecular materials, and are also important intermediates in organic synthesis because they contain alkynyl and hydroxyl groups in the molecules. The common preparation methods for propargyl alcohol usually rely on the transition metal catalyzed hydrogenation reaction and the alkynylation of ketones, which is high cost and with poor tolerance of the substitution groups. In this article, the hydrogenation reaction of alkynyl ketones with pinacolborane was developed with tetrabutylammonium bromide as catalyst. The present method provided a convenient, economical and efficient method for the synthesis of propargyl alcohol compounds.