Abstract
The production of chemicals in microbial cell factories is one of the effective ways to solve energy and environmental problems. Many chemical products have been produced by synthetic biology, but production ability and robustness of the strains still needs to been improved. Development of intelligent cell factory and realizing intelligent biological manufacturing is an important approach to improve the production and robustness. This review introduces the research status of intelligent biological manufacturing from five following aspects: protein design, biosensor, metabolism regulation, strain evolution and fermentation process. The development of biological "intelligence" will make an important contribution to improving the production level of industrial biological processes and process energy saving and emission reduction.
| Translated title of the contribution | Synthetic biological system construction and green intelligent biological manufacturing |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 3979-3994 |
| Number of pages | 16 |
| Journal | Huagong Xuebao/CIESC Journal |
| Volume | 71 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sept 2020 |