Abstract
Triterpenoids are widely present in nature and have received wide attention because of their anti-tumor, anti-viral, antibacterial, anti-inflammatory and immunomodulatory pharmacological activities. The compounds such as oleanolic acid, ursolic acid, glycyrrhizic acid and betulinic acid in natural triterpenes all showed good anti-viral activity. This review summarizes the advances of triterpenoids and their derivatives exemplified by tetracyclic triterpenes and pentacyclic triterpenes, and focusses on the structure-activity relationships and mechanisms of anti-HIV, anti-influenza, anti-coronavirus and anti-HBV/HCV. Thus, it would provide clues for rational design and development of novel anti-viral agents for the future.
| Translated title of the contribution | Structure-activity relationships and mechanisms of triterpenoids against virus |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 4071-4101 |
| Number of pages | 31 |
| Journal | Huagong Xuebao/CIESC Journal |
| Volume | 71 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sept 2020 |
