Dr. Jia Haiyang is a professor and doctoral supervisor at the School of Chemistry and Chemical Engineering, Beijing Institute of Technology. In 2019, he received his PhD in biology from the Max Planck Institute of Biochemistry, Germany, under the guidance of Professor Petra Schwille, member of the German Academy of Biochemistry. After that, he continued to do postdoctoral research in the same research group for one year. From 2020 to 2022, he worked as a Research Associate in the School of Chemistry, University of Bristol. The co-supervisor is Professor Stephen Mann (FRS), a Fellow of the Royal Society. In 2023, he will join Beijing Institute of Technology in the form of high-level talent introduction and be selected as a special Young Scholar of Beijing Institute of Technology. The research group has been engaged in the development of molecular regulation tools of synthetic biology and the construction and application of bionic systems for a long time. To meet the needs of bionic system to fine controllable and intelligent direction: 1) Take the lead in designing and developing micro-robots driven by protein molecular motors, breaking through the technical difficulties of building complex biological systems from scratch with nanoscale precision; 2) The invention of non-natural amino acid genetics tools to realize the intelligent manipulation of molecular behaviors such as protein self-assembly, localization and catalysis, and reveal the molecular mechanism of bacterial cytoskeleton dynamic self-assembly; 3) Temperature-sensitive RNA switches and gene circuits were designed to realize intelligent temperature-sensitive regulation of cell factory metabolism and artificial cell transcription translation. As the first/corresponding author of his research achievements, he has published 12 papers in important journals such as Nat Mater, Nat Commun, Angew Chem Int Ed, and one national patent has been authorized. He has participated in many domestic and foreign academic conferences and made oral reports, and has been invited to serve as an invited independent reviewer of Science Advances and Biotechnology Advances.
The development of molecular regulation tools in synthetic biology, the construction and application of bionic systems such as artificial cells, the design and engineering application of new artificial cell metabolism factories, the design and construction of 3D printed micro-robots based on biological macromolecules, the development of new antibodies and the research and development of high-throughput antibody screening technology, etc.
2015.06-2019.09, Max Planck Institute for Biochemistry, Major in Biology, Ph.D.
2012.09-2015.05, Beijing Institute of Technology, Chemical Engineering and Technology, Master of Engineering
2008.09-2012.06, Shihezi University, Bioscience major, Bachelor of Science
2023.02-present, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Professor
2020.09-2023.01, Research Associate, School of Chemistry, University of Bristol
2019.10-2020.08, Max Planck Institute for Biochemistry, Postdoc
1. Haiyang Jia; Johannes Flommersfeld; Michael Heymann; Sven K. Vogel; Henri G. Franquelim; David B. Brückner; Hiromune Eto; Chase P. Broedersz; Petra Schwille. 3D printed protein-based robotic structures actuated by molecular motor assemblies, Nature Materials, 2022, 21(6): 703-709(IF: 47.656)
2. Huan Sun; Haiyang Jia; Olivia Kendall; Jovan Dragelj; Vladimir Kubyshkin; Tobias Baumann; Maria-Andrea Mroginski; Petra Schwille; Nediljko Budisa. Halogenation of tyrosine perturbs large-scale protein self-organization[J]. Nature Communications, 2022, 13(1): 4843. (共同通讯作者,IF: 17.69)
3. Huan Sun; Haiyang Jia; Diego A Ramirez‐Diaz; Nediljko Budisa; Petra Schwille. Fine‐Tuning Protein Self‐Organization by Orthogonal Chemo‐Optogenetic Tools[J]. Angew. Chem. Int. Ed. Engl. , 2021, 133(9): 4551-4556. (共同第一作者,IF: 15.336)
4. Haiyang Jia; Thomas Litschel; Michael Heymann; Hiromune Eto; Henri G.Franquelim; Petra Schwille. Shaping giant membrane vesicles in 3D‐printed protein hydrogel cages[J]. Small, 2020, 16(27): 1906259.(封面文章,IF:13.281)
5. Haiyang Jia et al. Temperature-sensitive protein expression in protocells[J]. Chemical Communications, 2019, 55(45): 6421-6424. (IF:5.996)
6. Haiyang Jia, Petra Schwille. Bottom-up synthetic biology: reconstitution in space and time[J]. Current opinion in biotechnology, 2019, 60: 179-187. (IF:9.740)
7. Haiyang Jia; Lei Kai; Michael Heymann; Daniela A.García-Soriano; Tobias Härtel; Petra Schwille. Light-induced Printing of Protein Structures on Membranes in vitro[J]. Nano letters, 2018, 18(11): 7133-7140. (IF: 11.189)
8. Haiyang Jia; Michael Heymann; Frank Bernhard; Petra Schwille; Lei Kai. Cell-free protein synthesis in micro compartments: building a minimal cell from biobricks[J]. New biotechnology, 2017, 39: 199-205. (. 共同第一作, IF: 5.079)
9. Huan Sun; Haiyang Jia; Jun Li; Xudong Feng; ueqin Liu; Xiaohong Zhou; Chun Li. Rational synthetic combination genetic devices boosting high temperature ethanol fermentation [J]. Synthetic and systems biotechnology, 2017, 2(2): 121-129. (共同第一作者,IF: 4.33)
10. Haiyang Jia; Xiangying Sun; Huan Sun; Chenyi Li; Yunqian Wang; Xudong Fen; Chun Li; Intelligent Microbial Heat Regulating Engine (IMHeRE) for Improving Thermo-robustness and Efficiency of Bioconversion, ACS Synthetic Biology, 2016, 5(4): 312-320. (IF: 5.110)
11. Haiyang Jia; Yanshuang Fan; Xudong Feng; Chun Li. Enhancing stress-resistance for efficient microbial biotransformations by synthetic biology. Frontiers in Bioengineering and Biotechnology 2, 2014.00044. (IF: 5.48)
12. Genlin Zhang; Feng Qi; Haiyang Jia; Changling Zou; Chun Li. Advances in bioprocessing for efficient bio manufacture [J]. Rsc Advances, 2015, 5(65): 52444-52451.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):