Research output per year
Research output per year
Personal profile
Research Interests
At present, the main research direction of our research group is the regulation of RNA-mediated gene expression in bacteria, especially the regulation mechanism of pathogenic gene expression. The molecular mechanism of gene expression regulation at the RNA level was elucidate by means of biochemistry, structural biology and microbiology, providing theoretical basis and new ideas for the treatment of related diseases.
At present, the main research direction of our research group is the regulation of RNA-mediated gene expression in bacteria, especially the regulation mechanism of pathogenic gene expression. The molecular mechanism of gene expression regulation at the RNA level was elucidate by means of biochemistry, structural biology and microbiology, providing theoretical basis and new ideas for the treatment of related diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Recognition of cyclic dinucleotides and folates by human SLC19A1
Zhang, Q., Zhang, X., Zhu, Y., Sun, P., Zhang, L., Ma, J., Zhang, Y., Zeng, L., Nie, X., Gao, Y., Li, Z., Liu, S., Lou, J., Gao, A., Zhang, L. & Gao, P., 1 Dec 2022, In: Nature. 612, 7938, p. 170-176 7 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH
Gao, A., Vasilyev, N., Kaushik, A., Duan, W. & Serganov, A., 2021, In: Nucleic Acids Research. 48, 7, p. 3776-3788 13 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins
Zhu, Y., Gao, A., Zhan, Q., Wang, Y., Feng, H., Liu, S., Gao, G., Serganov, A. & Gao, P., 18 Apr 2019, In: Molecular Cell. 74, 2, p. 296-309.e7Research output: Contribution to journal › Article › peer-review
Open Access77 Citations (Scopus) -
Noncanonical features and modifications on the 5′-end of bacterial sRNAs and mRNAs
Vasilyev, N., Gao, A. & Serganov, A., 1 Mar 2019, In: Wiley interdisciplinary reviews. RNA. 10, 2, e1509.Research output: Contribution to journal › Review article › peer-review
Open Access12 Citations (Scopus) -
Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF
Gao, A., Vasilyev, N., Luciano, D. J., Levenson-Palmer, R., Richards, J., Marsiglia, W. M., Traaseth, N. J., Belasco, J. G. & Serganov, A., 27 Jul 2018, In: Nucleic Acids Research. 46, 13, p. 6841-6856 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus)