摘要
A highly efficient cinchona alkaloid-derived squaramide catalysed asymmetric Michael/cyclization cascade reaction of 4-arylmethylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones was successfully developed. This protocol provides an efficient and mild access to indanone-derived spiropyrrolidone scaffolds containing three contiguous stereocenters with two spiroquaternary stereocenters in excellent yields (up to 99%) with high enantio- and diastereoselectivities (up to 99% ee and up to >20 : 1 dr). This method provides an economical and practical approach for the asymmetric synthesis of medicinally relevant molecules.
源语言 | 英语 |
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页(从-至) | 7181-7185 |
页数 | 5 |
期刊 | Organic and Biomolecular Chemistry |
卷 | 19 |
期 | 33 |
DOI | |
出版状态 | 已出版 - 7 9月 2021 |
指纹
探究 'Squaramide-catalysed asymmetric Michael addition/cyclization cascade reaction of 4-arylmethylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones' 的科研主题。它们共同构成独一无二的指纹。引用此
Hou, X. Q., Wen, J. B., Yan, L., & Du, D. M. (2021). Squaramide-catalysed asymmetric Michael addition/cyclization cascade reaction of 4-arylmethylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones. Organic and Biomolecular Chemistry, 19(33), 7181-7185. https://doi.org/10.1039/d1ob01223a