Ions classification in peptide tandem mass spectra

Changyong Yu*, Guoren Wang, Wendan Zhai

*此作品的通讯作者

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

In computational proteomics, inferring the peptide sequence from its MS/MS data is an important issue and many algorithms have been proposed recently. Ions classification aiming at determining the type of ions provides a basis for most of the existing algorithms. However, no report on ions classification methods have been found to our knowledge. In this paper, a method extracting ion feature is first presented according to the analysis of the relationship among ions. To deal with ions with high overlap peaks and high density peaks in some mass interval, a method of filtering 'noise' peaks is then proposed according to the information of the related ions. Moreover, a binary ions classification method, which takes some type of ions as one class and the rest ions as the other class, is proposed based on SVM with a novel kernel trick. In the experiments, classification for bions and y-ions are implemented. The results demonstrate that an accuracy level of 90% is achieved.

源语言英语
主期刊名Proceedings - 5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008
412-416
页数5
DOI
出版状态已出版 - 2008
已对外发布
活动5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008 - Jinan, Shandong, 中国
期限: 18 10月 200820 10月 2008

出版系列

姓名Proceedings - 5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008
4

会议

会议5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008
国家/地区中国
Jinan, Shandong
时期18/10/0820/10/08

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引用此

Yu, C., Wang, G., & Zhai, W. (2008). Ions classification in peptide tandem mass spectra. 在 Proceedings - 5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008 (页码 412-416). 文章 4666420 (Proceedings - 5th International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2008; 卷 4). https://doi.org/10.1109/FSKD.2008.248