Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Zipeng Shen; Wei Zhu; Yajia Huang; Jiangjiang Zhang; Yifan Wu; Yinzhen Pan; Guang Yang; Dong Wang; Ying Li; Ben Zhong Tang

doi:10.1002/adhm.202300045

Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Zipeng Shen, Wei Zhu, Yajia Huang, Jiangjiang Zhang, Yifan Wu, Yinzhen Pan, Guang Yang, Dong Wang^*, Ying Li^*, Ben Zhong Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

Original language	English
Article number	2300045
Journal	Advanced healthcare materials
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/adhm.202300045
Publication status	Published - 21 Aug 2023
Externally published	Yes

Keywords

aggregation-induced emission
bacterial cellulose
photodynamic/photothermal therapy
wound dressings

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10.1002/adhm.202300045

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title = "Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria",

abstract = "Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.",

keywords = "aggregation-induced emission, bacterial cellulose, photodynamic/photothermal therapy, wound dressings",

author = "Zipeng Shen and Wei Zhu and Yajia Huang and Jiangjiang Zhang and Yifan Wu and Yinzhen Pan and Guang Yang and Dong Wang and Ying Li and Tang, {Ben Zhong}",

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doi = "10.1002/adhm.202300045",

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T1 - Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

AU - Shen, Zipeng

AU - Zhu, Wei

AU - Huang, Yajia

AU - Zhang, Jiangjiang

AU - Wu, Yifan

AU - Pan, Yinzhen

AU - Yang, Guang

AU - Wang, Dong

AU - Li, Ying

AU - Tang, Ben Zhong

PY - 2023/8/21

Y1 - 2023/8/21

N2 - Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

AB - Multidrug-resistant (MDR) bacteria-related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) is presented as wound dressings. BC-BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites show excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.

KW - aggregation-induced emission

KW - bacterial cellulose

KW - photodynamic/photothermal therapy

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ER -

Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria

Abstract

Keywords

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