UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats

Yunqi Li, Haixia Qiu, Hongyou Zhao, Biao Chang, Tengda Ji, Yidi Liu, Ying Gu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Osteoporosis is a bone disease associated with aging. As the population ages, osteoporosis has become a significant public health problem that threaten life quality of most countries in the world. Adequate vitamin D is able to improve intestinal calcium absorption, promote bone mineralization, maintain muscle strength, enhance balancing ability, and reduce fall risks, whichplays a vital role in bone metabolism. Moreover, vitamin D is mainly produced by ultraviolet (UV) light. The serum levels of 25(OH)D3 is the tools for estimating of the osteoporosis.It is known that vitamin D deficiency is ubiquitous in the elderly population, hence, we adopted UV light-emitting diode (UV-LED) instruments to generate narrow-range wavelengths of UV and determined its capability for producing vitamin D. The osteoporosis SD rats are our research subjects. The study was to investigate the effects of UV-LEDs of different power densities on vitamin D production. There are 4 groups 1/40.1, 0.2, 0.4, 0.8mW/cm2 and the rats (n = 6 per group) were irradiated with different power densities twice a week for a total of 8 weeks. The results showed that serum 25(OH)D3 levels rapidly increased in all irradiated groups compared with those in the control group (P < 0.001 in all groups), and 25(OH)D3 level of the rats in groups of both 0.4 and 0.8 m W/cm2 were able to return to the initial level at the fourth week after irradiation, besides, the group of 0.4 mW/ W/cm2 can achieve and maintain the highest25(OH)D3 level and so as the group of 0.8 m W/cm2 as the continuing irradiation. We demonstrate that the proper irradiation density of UV-LED irradiation can increase the production of vitamin D in rats and does not adversely affect the skin of rats.

Original languageEnglish
Title of host publicationOptics in Health Care and Biomedical Optics IX
EditorsQingming Luo, Qingming Luo, Xingde Li, Ying Gu, Yuguo Tang, Dan Zhu
PublisherSPIE
ISBN (Electronic)9781510630970
DOIs
Publication statusPublished - 2019
Externally publishedYes
EventOptics in Health Care and Biomedical Optics IX 2019 - Hangzhou, China
Duration: 21 Oct 201923 Oct 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11190
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceOptics in Health Care and Biomedical Optics IX 2019
Country/TerritoryChina
CityHangzhou
Period21/10/1923/10/19

Keywords

  • vitamin D UV-LED osteoporosis ultraviolet

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