Abstract
Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
Original language | English |
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Pages (from-to) | 1402-1407 |
Number of pages | 6 |
Journal | Advanced Materials |
Volume | 27 |
Issue number | 8 |
DOIs | |
Publication status | Published - 25 Feb 2015 |
Externally published | Yes |