Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun, Lu Zhang, Jiuling Wang, Qiang Feng, Dingbin Liu, Qifang Yin, Dongyan Xu, Yujie Wei, Baoquan Ding, Xinghua Shi*, Xingyu Jiang

*Corresponding author for this work

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Abstract

Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

Original languageEnglish
Pages (from-to)1402-1407
Number of pages6
JournalAdvanced Materials
Volume27
Issue number8
DOIs
Publication statusPublished - 25 Feb 2015
Externally publishedYes

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Sun, J., Zhang, L., Wang, J., Feng, Q., Liu, D., Yin, Q., Xu, D., Wei, Y., Ding, B., Shi, X., & Jiang, X. (2015). Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake. Advanced Materials, 27(8), 1402-1407. https://doi.org/10.1002/adma.201404788