Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun, Lu Zhang, Jiuling Wang, Qiang Feng, Dingbin Liu, Qifang Yin, Dongyan Xu, Yujie Wei, Baoquan Ding, Xinghua Shi*, Xingyu Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

399 Citations (Scopus)

Abstract

Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

Original languageEnglish
Pages (from-to)1402-1407
Number of pages6
JournalAdvanced Materials
Volume27
Issue number8
DOIs
Publication statusPublished - 25 Feb 2015
Externally publishedYes

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