Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun; Lu Zhang; Jiuling Wang; Qiang Feng; Dingbin Liu; Qifang Yin; Dongyan Xu; Yujie Wei; Baoquan Ding; Xinghua Shi; Xingyu Jiang

doi:10.1002/adma.201404788

Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun, Lu Zhang, Jiuling Wang, Qiang Feng, Dingbin Liu, Qifang Yin, Dongyan Xu, Yujie Wei, Baoquan Ding, Xinghua Shi^*, Xingyu Jiang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

399 Citations (Scopus)

Abstract

Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

Original language	English
Pages (from-to)	1402-1407
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	8
DOIs	https://doi.org/10.1002/adma.201404788
Publication status	Published - 25 Feb 2015
Externally published	Yes

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abstract = "Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.",

author = "Jiashu Sun and Lu Zhang and Jiuling Wang and Qiang Feng and Dingbin Liu and Qifang Yin and Dongyan Xu and Yujie Wei and Baoquan Ding and Xinghua Shi and Xingyu Jiang",

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AU - Sun, Jiashu

AU - Zhang, Lu

AU - Wang, Jiuling

AU - Feng, Qiang

AU - Liu, Dingbin

AU - Yin, Qifang

AU - Xu, Dongyan

AU - Wei, Yujie

AU - Ding, Baoquan

AU - Shi, Xinghua

AU - Jiang, Xingyu

PY - 2015/2/25

Y1 - 2015/2/25

N2 - Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

AB - Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.

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VL - 27

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JO - Advanced Materials

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Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Abstract

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