The determination of thiols based using a probe that utilizes both an absorption red-shift and fluorescence enhancement

Baocun Zhu, Xiaoling Zhang*, Hongying Jia, Yamin Li, Shutang Chen, Sichun Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

A pyridylvinylene derivative containing piazselenole displayed high selectivity toward glutathione in the presence of other biorelevant analytes. The compound exhibited a 19 nm red-shift in absorption spectra and ∼3-fold fluorescence intensity enhancement; in addition, it was possible to detect micromolar amounts of glutathione quantitatively using both red-shift absorbance and enhanced fluorescence. The mechanism of the reaction between the modified pyridylvinylene derivative and glutathione was confirmed using ESI-MS and absorption/fluorescence spectra.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalDyes and Pigments
Volume86
Issue number1
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Fluorescence enhancement
  • Glutathione
  • Intramolecular charge transfer
  • Red-shift
  • Thiol probe
  • Two-channel

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