Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

Honggang Liang; Lingxiang Bao; Yao Du; Yiying Zhang; Siping Pang; Chenghui Sun

doi:10.1055/s-0036-1588533

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

Honggang Liang, Lingxiang Bao, Yao Du, Yiying Zhang, Siping Pang, Chenghui Sun^*

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan-amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

Original language	English
Pages (from-to)	2675-2679
Number of pages	5
Journal	Synlett
Volume	28
Issue number	19
DOIs	https://doi.org/10.1055/s-0036-1588533
Publication status	Published - 1 Dec 2017

Keywords

allylic amines
cyanamides
cyanation
cyanogen bromide
deallylation

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10.1055/s-0036-1588533

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abstract = "Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan-amides through an N-deallylation reaction and an N-cyanation reaction in one pot.",

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author = "Honggang Liang and Lingxiang Bao and Yao Du and Yiying Zhang and Siping Pang and Chenghui Sun",

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AU - Liang, Honggang

AU - Bao, Lingxiang

AU - Du, Yao

AU - Zhang, Yiying

AU - Pang, Siping

AU - Sun, Chenghui

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan-amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

AB - Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan-amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

KW - allylic amines

KW - cyanamides

KW - cyanation

KW - cyanogen bromide

KW - deallylation

UR - http://www.scopus.com/inward/record.url?scp=85027975773&partnerID=8YFLogxK

U2 - 10.1055/s-0036-1588533

DO - 10.1055/s-0036-1588533

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EP - 2679

JO - Synlett

JF - Synlett

IS - 19

ER -

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

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Keywords

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