Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

Yi Liu; Yu Lin Deng; Rong Zheng; Pei Long Zhang; Hui Zhai; Ke Zhong Liu; Chang Jin Zhu

Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

Yi Liu^*, Yu Lin Deng, Rong Zheng, Pei Long Zhang, Hui Zhai, Ke Zhong Liu, Chang Jin Zhu

^*Corresponding author for this work

School of Medical and Technology

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

Original language	English
Pages (from-to)	599-602
Number of pages	4
Journal	Chinese Chemical Letters
Volume	17
Issue number	5
Publication status	Published - May 2006

Keywords

Cytotoxicity
Phospholipid conjugate
Polyamide

Cite this

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title = "Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid",

abstract = "In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.",

keywords = "Cytotoxicity, Phospholipid conjugate, Polyamide",

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T1 - Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

AU - Liu, Yi

AU - Deng, Yu Lin

AU - Zheng, Rong

AU - Zhang, Pei Long

AU - Zhai, Hui

AU - Liu, Ke Zhong

AU - Zhu, Chang Jin

PY - 2006/5

Y1 - 2006/5

N2 - In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

AB - In order to increase the cell penetration and decrease the cytotoxicity of the synthetic molecule, we designed and synthesized a DNA-binding ligand, which was a conjugate of polyamide and phospholipid. We examined the differences in the effect on cytotoxicity between the conjugate and the native polyamide. As expected that the in vitro cytotoxicity of the conjugate was obviously lower than that of the native polyamide either in HeLa cells or SH-SY5Y neuroblastoma cells.

KW - Cytotoxicity

KW - Phospholipid conjugate

KW - Polyamide

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M3 - Article

AN - SCOPUS:33745836747

SN - 1001-8417

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SP - 599

EP - 602

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

ER -

Synthesis and in vitro cytotoxicity of a novel conjugate of polyamide and phospholipid

Abstract

Keywords

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