Studies on the cyclization reaction of d-aspartic acid

Yu Chuan Li; Si Ping Pang; Yong Zhong Yu

doi:10.1016/j.cclet.2007.03.013

Studies on the cyclization reaction of d-aspartic acid

Yu Chuan Li, Si Ping Pang^*, Yong Zhong Yu

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The cyclization reaction of d-aspartic acid was studied, the carboxyl groups of d-aspartic acid were protected by benzyl alcohol to give compound d-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine-2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of d-dibenzyl aspartate, respectively, and their structures were confirmed by ¹H NMR and MS. Both cyclization reaction conditions were also investigated in detail.

Original language	English
Pages (from-to)	516-518
Number of pages	3
Journal	Chinese Chemical Letters
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.cclet.2007.03.013
Publication status	Published - May 2007

Keywords

3,6-Disubstituted piperazine-2,5-diones
Azetidine-2-ones
Cyclization reaction
d-Aspartic acid

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10.1016/j.cclet.2007.03.013

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title = "Studies on the cyclization reaction of d-aspartic acid",

abstract = "The cyclization reaction of d-aspartic acid was studied, the carboxyl groups of d-aspartic acid were protected by benzyl alcohol to give compound d-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine-2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of d-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail.",

keywords = "3,6-Disubstituted piperazine-2,5-diones, Azetidine-2-ones, Cyclization reaction, d-Aspartic acid",

author = "Li, {Yu Chuan} and Pang, {Si Ping} and Yu, {Yong Zhong}",

year = "2007",

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doi = "10.1016/j.cclet.2007.03.013",

language = "English",

volume = "18",

pages = "516--518",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

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T1 - Studies on the cyclization reaction of d-aspartic acid

AU - Li, Yu Chuan

AU - Pang, Si Ping

AU - Yu, Yong Zhong

PY - 2007/5

Y1 - 2007/5

N2 - The cyclization reaction of d-aspartic acid was studied, the carboxyl groups of d-aspartic acid were protected by benzyl alcohol to give compound d-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine-2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of d-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail.

AB - The cyclization reaction of d-aspartic acid was studied, the carboxyl groups of d-aspartic acid were protected by benzyl alcohol to give compound d-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine-2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of d-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail.

KW - 3,6-Disubstituted piperazine-2,5-diones

KW - Azetidine-2-ones

KW - Cyclization reaction

KW - d-Aspartic acid

UR - http://www.scopus.com/inward/record.url?scp=34247571976&partnerID=8YFLogxK

U2 - 10.1016/j.cclet.2007.03.013

DO - 10.1016/j.cclet.2007.03.013

M3 - Article

AN - SCOPUS:34247571976

SN - 1001-8417

VL - 18

SP - 516

EP - 518

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

ER -

Studies on the cyclization reaction of d-aspartic acid

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Keywords

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