Structurally well-defined, recoverable C3-symmetric tris(β-hydroxy phosphoramide)-catalyzed enantioselective borane reduction of ketones

Da Ming Du*, Tao Fang, Jiaxi Xu, Shi Wei Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

A series of new chiral C3-symmetric tris(β-hydroxy phosphoramide) ligands have been synthesized via the reaction of trisphosphoramide ester and Grignard reagents. The catalytic asymmetric borane reduction of ketones with these new C3-symmetric chiral tris(β-hydroxy phosphoramide)s was investigated. Structurally well-defined, recoverable ligand 1d is an efficient catalyst for the enantioselective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were achieved (up to 98% ee).

Original languageEnglish
Pages (from-to)1327-1330
Number of pages4
JournalOrganic Letters
Volume8
Issue number7
DOIs
Publication statusPublished - 30 Mar 2006
Externally publishedYes

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