Abstract
A series of new chiral C3-symmetric tris(β-hydroxy phosphoramide) ligands have been synthesized via the reaction of trisphosphoramide ester and Grignard reagents. The catalytic asymmetric borane reduction of ketones with these new C3-symmetric chiral tris(β-hydroxy phosphoramide)s was investigated. Structurally well-defined, recoverable ligand 1d is an efficient catalyst for the enantioselective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were achieved (up to 98% ee).
Original language | English |
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Pages (from-to) | 1327-1330 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 7 |
DOIs | |
Publication status | Published - 30 Mar 2006 |
Externally published | Yes |