TY - JOUR
T1 - Strategies to construct efficient singlet oxygen-generating photosensitizers
AU - Pang, E.
AU - Zhao, Shaojing
AU - Wang, Benhua
AU - Niu, Guangle
AU - Song, Xiangzhi
AU - Lan, Minhuan
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Singlet oxygen (1O2) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of 1O2 is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of 1O2. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the 1O2 QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high 1O2 generation efficiency and propose directions for future clinical applications of PDT.
AB - Singlet oxygen (1O2) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of 1O2 is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of 1O2. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the 1O2 QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high 1O2 generation efficiency and propose directions for future clinical applications of PDT.
KW - Aggregation-induced emission
KW - Intersystem crossing
KW - Photodynamic therapy
KW - Photosensitizer
KW - Singlet oxygen quantum yield
UR - http://www.scopus.com/inward/record.url?scp=85136470890&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2022.214780
DO - 10.1016/j.ccr.2022.214780
M3 - Review article
AN - SCOPUS:85136470890
SN - 0010-8545
VL - 472
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 214780
ER -
