TY - JOUR
T1 - Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear
AU - Qi, Jieyu
AU - Huang, Wenjuan
AU - Lu, Yicheng
AU - Yang, Xuehan
AU - Zhou, Yinyi
AU - Chen, Tian
AU - Wang, Xiaohan
AU - Yu, Yafeng
AU - Sun, Jia Qiang
AU - Chai, Renjie
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of hair cells is a main cause of sensorineural hearing loss, and currently, the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids, but these are of limited benefit in patients. It is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective strategies. At present, how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing research. Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells, and in this article, we first review the principal mechanisms underlying hair cell reproduction. We then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration, and we summarize current achievements in hair cell regeneration. Lastly, we discuss potential future approaches, such as small molecule drugs and gene therapy, which might be applied for regenerating functional hair cells in the clinic.
AB - Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of hair cells is a main cause of sensorineural hearing loss, and currently, the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids, but these are of limited benefit in patients. It is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective strategies. At present, how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing research. Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells, and in this article, we first review the principal mechanisms underlying hair cell reproduction. We then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration, and we summarize current achievements in hair cell regeneration. Lastly, we discuss potential future approaches, such as small molecule drugs and gene therapy, which might be applied for regenerating functional hair cells in the clinic.
KW - Cochlea
KW - Hair cell regeneration
KW - Hearing loss
KW - Stem cell
UR - http://www.scopus.com/inward/record.url?scp=85173080006&partnerID=8YFLogxK
U2 - 10.1007/s12264-023-01130-w
DO - 10.1007/s12264-023-01130-w
M3 - Review article
C2 - 37787875
AN - SCOPUS:85173080006
SN - 1673-7067
VL - 40
SP - 113
EP - 126
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
IS - 1
ER -