Site-Selective Binding of Peripheral Chiral Guests Induces Stereospecificity in A4L6 Tetrahedral Anion Cages

Boyang Li, Bo Zheng, Wenyao Zhang, Dan Zhang, Xiao Juan Yang, Biao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Herein we report an unprecedented chiral induction of anion-coordination-driven tetrahedra (A4L6-type) by peripheral guests, S-, R-α-methylcholine and S-, R-β-methylcholine, which are bound along the tetrahedral edges in a highly site-specific fashion. This "peripheral templation", which has proven indispensable for the formation of tetrahedral structure, is also an effective approach to encoding chiral information to the tetrahedron. Moreover, the site-selective binding of chiral choline derivatives to the anion cage with induced one-handedness may imply applications of such metal-free, labile systems in the study of biological processes such as selective recognition of structurally similar molecules.

Original languageEnglish
Article number0c00882
Pages (from-to)6304-6311
Number of pages8
JournalJournal of the American Chemical Society
Volume142
Issue number13
DOIs
Publication statusPublished - 1 Apr 2020
Externally publishedYes

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