Separation of 2-HPA by capillary electrophoresis

Rongji Dai; Lin Yang; Wei Liu; Yulin Deng

doi:10.1109/ICCME.2007.4382074

Separation of 2-HPA by capillary electrophoresis

Rongji Dai, Lin Yang, Wei Liu, Yulin Deng^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, β-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.

Original language	English
Title of host publication	2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
Pages	1879-1882
Number of pages	4
DOIs	https://doi.org/10.1109/ICCME.2007.4382074
Publication status	Published - 2007
Event	2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 - Beijing, China Duration: 23 May 2007 → 27 May 2007

Publication series

Name	2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

Conference

Conference	2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
Country/Territory	China
City	Beijing
Period	23/05/07 → 27/05/07

Keywords

2-HPA
Capillary electrophoresis
Chiral separation
Dansylchloride

Access to Document

10.1109/ICCME.2007.4382074

Cite this

@inproceedings{e4ba99dcd85546beb5b95c615a6a1f2d,

title = "Separation of 2-HPA by capillary electrophoresis",

abstract = "The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, β-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.",

keywords = "2-HPA, Capillary electrophoresis, Chiral separation, Dansylchloride",

author = "Rongji Dai and Lin Yang and Wei Liu and Yulin Deng",

year = "2007",

doi = "10.1109/ICCME.2007.4382074",

language = "English",

isbn = "1424410789",

series = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007",

pages = "1879--1882",

booktitle = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007",

note = "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 ; Conference date: 23-05-2007 Through 27-05-2007",

}

Dai, R, Yang, L, Liu, W & Deng, Y 2007, Separation of 2-HPA by capillary electrophoresis. in 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007., 4382074, 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007, pp. 1879-1882, 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007, Beijing, China, 23/05/07. https://doi.org/10.1109/ICCME.2007.4382074

Separation of 2-HPA by capillary electrophoresis. / Dai, Rongji; Yang, Lin; Liu, Wei et al.
2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007. 2007. p. 1879-1882 4382074 (2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Separation of 2-HPA by capillary electrophoresis

AU - Dai, Rongji

AU - Yang, Lin

AU - Liu, Wei

AU - Deng, Yulin

PY - 2007

Y1 - 2007

N2 - The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, β-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.

AB - The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, β-CD concentration, electrolyte concentration and temperature et al. on the chiral separation are investigated in detail. CE is shown to be a simple, efficient, and inexpensive way to separate these three chiral compounds in laboratory.

KW - 2-HPA

KW - Capillary electrophoresis

KW - Chiral separation

KW - Dansylchloride

UR - http://www.scopus.com/inward/record.url?scp=48149105282&partnerID=8YFLogxK

U2 - 10.1109/ICCME.2007.4382074

DO - 10.1109/ICCME.2007.4382074

M3 - Conference contribution

AN - SCOPUS:48149105282

SN - 1424410789

SN - 9781424410781

T3 - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

SP - 1879

EP - 1882

BT - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

T2 - 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

Y2 - 23 May 2007 through 27 May 2007

ER -

Separation of 2-HPA by capillary electrophoresis

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

Cite this