Resting-state dynamic functional connectivity in major depressive disorder: A systematic review

Shuting Sun, Chang Yan*, Shanshan Qu, Gang Luo, Xuesong Liu, Fuze Tian, Qunxi Dong, Xiaowei Li, Bin Hu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

As a novel measure, dynamic functional connectivity (dFC) provides insight into the dynamic nature of brain networks and their interactions in resting-state, surpassing traditional static functional connectivity in pathological conditions such as depression. Since a comprehensive review is still lacking, we then reviewed forty-five eligible papers to explore pathological mechanisms of major depressive disorder (MDD) from perspectives including abnormal brain regions and functional networks, brain state, topological properties, relevant recognition, along with longitudinal studies. Though inconsistencies could be found, common findings are: (1) From different perspectives based on dFC, default-mode network (DMN) with its subregions exhibited a close relation to the pathological mechanism of MDD. (2) With a corrupted integrity within large-scale functional networks and imbalance between them, longer fraction time in a relatively weakly-connected state may be a possible property of MDD concerning its relation with DMN. Abnormal transition frequencies between states were correlated to the severity of MDD. (3) Including dynamic properties in topological network metrics enhanced recognition effect. In all, this review summarized its use for clinical diagnosis and treatment, elucidating the non-stationary of MDD patients' aberrant brain activity in the absence of stimuli and bringing new views into its underlying neuro mechanism.

Original languageEnglish
Article number111076
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume135
DOIs
Publication statusPublished - 20 Dec 2024

Keywords

  • Classification
  • Depression
  • Dynamic functional connectivity
  • Graph theory
  • Major depressive disorder
  • Resting-state

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