Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui*, Jian Yang, Qunfang Zhou, Ping Liang, Yaling Wang, Xueyun Gao, Yongtian Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

Original languageEnglish
Pages (from-to)5900-5906
Number of pages7
JournalACS applied materials & interfaces
Volume9
Issue number7
DOIs
Publication statusPublished - 22 Feb 2017

Keywords

  • X-ray CT imaging
  • photothermal therapy
  • protein
  • renal clearable
  • silver nanodots

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