Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss

Jin Guo, Renjie Chai, Huawei Li, Shan Sun*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

44 Citations (Scopus)

Abstract

Hair cells are specialized sensory epithelia cells that receive mechanical sound waves and convert them into neural signals for hearing, and these cells can be killed or damaged by ototoxic drugs, including many aminoglycoside antibiotics, platinum-based anticancer agents, and loop diuretics, leading to drug-induced hearing loss. Studies of therapeutic approaches to drug-induced hearing loss have been hampered by the limited understanding of the biological mechanisms that protect and regenerate hair cells. This review briefly discusses some of the most common ototoxic drugs and describes recent research concerning the mechanisms of ototoxic drug-induced hearing loss. It also highlights current developments in potential therapies and explores current clinical treatments for patients with hearing impairments.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages17-36
Number of pages20
DOIs
Publication statusPublished - 2019
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1130
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Aminoglycosides
  • Hair cell
  • Mitochondrial DNA
  • Ototoxicity
  • Reactive oxygen species

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