Preparation of porous carboxymethyl chitosan grafted poly (acrylic acid) superabsorbent by solvent precipitation and its application as a hemostatic wound dressing

Yu Chen*, Yong Zhang, Fengju Wang, Weiwei Meng, Xinlin Yang, Peng Li, Jianxin Jiang, Huimin Tan, Yongfa Zheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic wound dressing was investigated. The results indicate that the modified superabsorbent polymer is non-cytotoxic. It showed a high swelling capacity and better hemostatic performance in the treatments of hemorrhage model of ear artery, arteria cruralis and spleen of the New Zealand white rabbit than the unmodified polymer and other commonly used clinic wound dressings. The hemostatic mechanism of the porous CMCTS-g-PAA polymer was also discussed.

Original languageEnglish
Pages (from-to)18-29
Number of pages12
JournalMaterials Science and Engineering C
Volume63
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • Chitosan
  • Hemostatic wound dressing
  • Modification
  • Solvent precipitation method
  • Superabsorbent polymer

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