One-Pot Synthesis of Customized Metal–Phenolic-Network-Coated AIE Dots for In Vivo Bioimaging

Changhuo Xu, Chen Peng*, Xueqin Yang, Ruoyao Zhang, Zheng Zhao*, Bo Yan, Jun Zhang, Junyi Gong, Xuewen He, Ryan T.K. Kwok, Jacky W.Y. Lam, Ben Zhong Tang*

*Corresponding author for this work

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Abstract

The integration of aggregation-induced emission luminogens (AIEgens) and inorganic constituents to generate multifunctional nanocomposites has attracted much attention because it couples the bright aggregate-state fluorescence of AIEgens with the diverse imaging modalities of inorganic constituents. Herein, a facile and universal strategy to prepare metal–phenolic-network (MPN)-coated AIE dots in a high encapsulation efficiency is reported. Through precise control on the nucleation of AIEgens and deposition of MPNs in tetrahydrofuran/water mixtures, termed as coacervation, core–shell MPN-coated AIE dots with bright emission are assembled in a one-pot fashion. The optical properties of MPN-coated AIE dots can be readily tuned by varying the incorporated AIEgens. Different metal ions, such as Fe3+, Ti4+, Cu2+, Ni2+, can be introduced to the nanoparticles. The MPN-coated AIE dots with a red-emissive AIEgen core are successfully used to perform magnetic resonance/fluorescence dual-modality imaging in a tumor-bearing mouse model and blood flow visualization in a zebrafish larva. It is believed that the present study provides a tailor-made nanoplatform to meet the individual needs of in vivo bioimaging.

Original languageEnglish
Article number2104997
JournalAdvanced Science
Volume9
Issue number11
DOIs
Publication statusPublished - 14 Apr 2022
Externally publishedYes

Keywords

  • aggregation-induced emission
  • coacervation
  • fluorescence imaging
  • magnetic resonance imaging
  • metal–phenolic networks

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Xu, C., Peng, C., Yang, X., Zhang, R., Zhao, Z., Yan, B., Zhang, J., Gong, J., He, X., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2022). One-Pot Synthesis of Customized Metal–Phenolic-Network-Coated AIE Dots for In Vivo Bioimaging. Advanced Science, 9(11), Article 2104997. https://doi.org/10.1002/advs.202104997