Abstract
A new method was studied to synthesize 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine. 4(5)-(3-pyridyl)imidazole sodium salt was obtained from 3-(α-aminoacetyl)pyridine hydrochloride by formylation, cyclization and deprotonation. 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine was then synthesized via condensation of 4(5)-(3-pyridyl)imidazole sodium salt with N-(4-bromobutyl)phthalimide followed by hydrazinolysis. The gross yield is 54%. The new synthetic method is practical and efficient for its mild reaction conditions and the features of high yield and high purity.
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 4 |
| Journal | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| Volume | 27 |
| Issue number | SUPPL. 2 |
| Publication status | Published - Dec 2007 |
Keywords
- 4(5)-(3-pyridyl) imidazole
- 4-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanamine
- Synthesis
- Telithromycin