Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

Hui Li; Li Li Tan; Peng Jia; Qing Lan Li; Yu Long Sun; Jian Zhang; Yong Qiang Ning; Jihong Yu; Ying Wei Yang

doi:10.1039/c4sc00198b

Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

Hui Li, Li Li Tan, Peng Jia, Qing Lan Li, Yu Long Sun, Jian Zhang, Yong Qiang Ning, Jihong Yu, Ying Wei Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

219 Citations (Scopus)

Abstract

We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4] arene (SC[4]A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ring-stalk binding affinity, leading to the dissociation of SC[4]A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.

Original language	English
Pages (from-to)	2804-2808
Number of pages	5
Journal	Chemical Science
Volume	5
Issue number	7
DOIs	https://doi.org/10.1039/c4sc00198b
Publication status	Published - Jul 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c4sc00198b

Cite this

@article{9dee1e0443834938ac02ec2cc8ba2adb,

title = "Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods",

abstract = "We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4] arene (SC[4]A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ring-stalk binding affinity, leading to the dissociation of SC[4]A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.",

author = "Hui Li and Tan, {Li Li} and Peng Jia and Li, {Qing Lan} and Sun, {Yu Long} and Jian Zhang and Ning, {Yong Qiang} and Jihong Yu and Yang, {Ying Wei}",

year = "2014",

month = jul,

doi = "10.1039/c4sc00198b",

language = "English",

volume = "5",

pages = "2804--2808",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

AU - Li, Hui

AU - Tan, Li Li

AU - Jia, Peng

AU - Li, Qing Lan

AU - Sun, Yu Long

AU - Zhang, Jian

AU - Ning, Yong Qiang

AU - Yu, Jihong

AU - Yang, Ying Wei

PY - 2014/7

Y1 - 2014/7

N2 - We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4] arene (SC[4]A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ring-stalk binding affinity, leading to the dissociation of SC[4]A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.

AB - We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4] arene (SC[4]A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ring-stalk binding affinity, leading to the dissociation of SC[4]A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.

UR - http://www.scopus.com/inward/record.url?scp=84901846116&partnerID=8YFLogxK

U2 - 10.1039/c4sc00198b

DO - 10.1039/c4sc00198b

M3 - Article

AN - SCOPUS:84901846116

SN - 2041-6520

VL - 5

SP - 2804

EP - 2808

JO - Chemical Science

JF - Chemical Science

IS - 7

ER -

Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica-coated gold nanorods

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this